SAE1 Protein

SUMO1 activating enzyme subunit 1

SAE1 Products

SAE1 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
SAE1	Human	SAE1 Protein, Recombinant, with GST Tag	13921-H20B

SAE1 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
SAE1	Human	Human SAE1 Gene cDNA Clone / ORF Clone	HG13921-G

SAE1 Alternative Names

AOS1, HSPC140, SUA1, UBLE1A, SUMO-1 activating enzyme E1 N subunit, SUMO-1 activating enzyme subunit 1, SUMO-activating enzyme subunit 1, activator of SUMO1, sentrin/SUMO-activating protein AOS1, ubiquitin-like 1-activating enzyme E1A, ubiquitin-like protein SUMO-1 activating enzyme [Homo sapiens]

2400010M20Rik, 2610044L12Rik, AL033372, AOS1, AW743391, D7Ertd177e, HSPC140, Sua1, Uble1a, SUMO-1 activating enzyme subunit 1, SUMO-activating enzyme subunit 1, ubiquitin-like (sentrin) activating enzyme E1A, ubiquitin-like 1 (sentrin) activating enzyme E1A, ubiquitin-like 1 (sentrin) activating enzyme subunit 1, ubiquitin-like 1-activating enzyme E1A [Mus musculus]

SAE1 Background

SAE1 belongs to the ubiquitin-activating E1 family. It is a heterodimer that acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It functions as a UBLI E1 ligase mediating the ATP-dependent activation of UBL1. SAE1 binds with UBLE1A and UBLE1B to form a heterodimer which can bind UBL1. SAE1 also regulates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2. SAE1 and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins.

SAE1 Related Studies

1. Gong L, et al. (1999) Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex. FEBS Lett. 448(1):185-9.
2. Lois LM, et al. (2005) Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1. EMBO J. 24(3):439-51.
3. Tatham MH, et al. (2001) Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. J Biol Chem. 276(38):35368-74.