Anti-SAE1 Antibody

Cat: 13921-RP01
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Anti-SAE1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-SAE1 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human SAE1
Recombinant Human SAE1 protein (Catalog#13921-H20B)
Produced in rabbits immunized with purified, recombinant Human SAE1 (rh SAE1; Catalog#13921-H20B; Q9UBE0; Met1-Lys346). Total IgG was purified by Protein A affinity chromatography.
Polyclonal Rabbit IgG
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-SAE1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-SAE1 Antibody Alternative Names
Anti-AOS1 Antibody;Anti-HSPC140 Antibody;Anti-SUA1 Antibody;Anti-UBLE1A Antibody
SAE1 Background Information

SAE1 belongs to the ubiquitin-activating E1 family. It is a heterodimer that acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It functions as a UBLI E1 ligase mediating the ATP-dependent activation of UBL1. SAE1 binds with UBLE1A and UBLE1B to form a heterodimer which can bind UBL1. SAE1 also regulates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2. SAE1 and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins.

Full Name
SUMO1 activating enzyme subunit 1
  • Gong L, et al. (1999) Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex. FEBS Lett. 448(1):185-9.
  • Lois LM, et al. (2005) Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1. EMBO J. 24(3):439-51.
  • Tatham MH, et al. (2001) Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. J Biol Chem. 276(38):35368-74.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-SAE1 Antibody Mouse Monoclonal ELISA 13921-MM01
    Anti-SAE1 Antibody Rabbit Polyclonal WB,ELISA,IP 13921-T52
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