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> S100A8 Protein & Antibody S100A8 Protein & Antibody
S100 calcium binding protein A8
S100A8 Products
S100A8 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| S100A8 | Human | S100A8 Protein, Recombinant |
11138-H08B |
| S100A8 | Human | S100A8 Protein, Recombinant |
11138-H07E |
11138-H08B: Measured by its ability to bind recombinant human S100A9 in a functional ELISA.
11138-H07E: Measured by its ability to bind recombinant human S100A9 in a functional ELISA.
S100A8 Antibody
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human S100A8 |
WB, ELISA | S100A8 Antibody, Rabbit PAb | 11138-RP01 |
| Human S100A8 |
WB, ELISA | S100A8 Antibody, Rabbit PAb (Antigen Affinity Purified) | 11138-RP02 |
| Human S100A8 |
WB, ELISA | S100A8 Antibody | 11138-R101 |
S100A8 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| S100A8 | Human | Homo sapiens S100A8 cDNA Clone(NM_002964.3) | HG11138-M |
| S100A8 | Mouse | Mus musculus S100A8 cDNA Clone | MG50228-M |
S100A8 Related Areas
Signal Transduction>>Calcium Signaling>>Calcium Binding Protein>>S100 Protein>>S100A8
Cancer>>Cancer Biomarkers>>S100A8
S100A8 Alternative Names
S100A8, 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8, MRP-8, calgranulin A, calgranulin-A [Homo sapiens]
S100a8, 60B8Ag, AI323541, B8Ag, CFAg, CP-10, Caga, MRP8, p8, MRP-8, calgranulin-A [Mus musculus]
S100A8 Related Products
Protein Products
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! |
| S100A1 | Human | S100A1/Fc Protein, Recombinant |
| S100A2 | Human | S100A2/Fc Protein, Recombinant |
| S100A2 | Human | S100A2 Protein, Recombinant |
| S100A4 | Human | S100A4/Fc Protein, Recombinant |
| S100A6 | Human | S100A6 Protein, Recombinant |
| S100A6 | Human | S100A6 Protein, Recombinant |
| S100A6 | Mouse | S100A6 Protein, Recombinant |
| S100A7 | Human | S100A7 Protein, Recombinant |
| S100A9 | Human | S100A9 Protein, Recombinant |
| S100A9 | Human | S100A9 Protein, Recombinant |
| S100A11/S100C | Human | S100A11/S100C Protein, Recombinant |
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S100A12 |
Human |
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S100A13 |
Human |
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| S100A14 | Human | S100A14 Protein, Recombinant |
| S100A16 | Human | S100A16 Protein, Recombinant, Native |
| S100B | Human | S100B/Fc Protein, Recombinant |
Antibody Products
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! |
| Mouse S100A6 |
WB, ELISA | S100A6 Antibody, Rabbit MAb |
| Mouse S100A6 |
WB, ELISA | Rabbit Polyclonal Antibody |
| Mouse S100A6 |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) |
| Human S100A9 |
WB, ELISA | S100A9 Antibody, Rabbit PAb |
| Human S100A9 |
WB, ELISA | S100A9 Antibody, Rabbit PAb (Antigen Affinity Purified) |
| Human S100A12 |
WB, ELISA | S100A12 Antibody, Rabbit PAb |
| Human S100A12 |
WB, ELISA | S100A12 Antibody, Rabbit PAb (Antigen Affinity Purified) |
| Human S100A13 |
WB, ELISA | S100A13 Antibody, Mouse MAb |
| Human S100A13 |
WB, ELISA | S100A13 Antibody, Rabbit PAb |
| Human S100A13 |
WB, ELISA | S100A13 Antibody, Rabbit PAb (Antigen Affinity Purified) |
cDNA Clone Products
S100A8 Background
S100A8 is a member of the S100 protein family containing 2EF-hand calcium-binding motifs. S100 proteins are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. Altered expression of S100A8 protein is associated with various diseases and cancers. S100A8 may have an immunoregulatory role by contributing to the regulation of fetal-maternal interactions. It may play a protective role and its absence may allow infiltration by maternal cells, a process eventually manifesting as resorption. The heterodimeric S100 protein complex S100A8/A9 which has been shown to be involved in inflammatory and neoplastic disorders. The complex can induce cell proliferation, or apoptosis, inflammation, collagen synthesis, and cell migration. S100A8/A9 has emerged as important pro-inflammatory mediator in acute and chronic inflammation. More recently, increased S100A8 and S100A9 levels were also detected in various human cancers, presenting abundant expression in neoplastic tumor cells as well as infiltrating immune cells. On the one hand, S100A8/A9 is a powerful apoptotic agent produced by immune cells, making it a very fascinating tool in the battle against cancer. It spears the risk to induce auto-immune response and may serve as a lead compound for cancer-selective therapeutics. In contrast, S100A8/A9 expression in cancer cells has also been associated with tumor development, cancer invasion or metastasis. Altogether, its expression and potential cytokine-like function in inflammation and in cancer suggests that S100A8/A9 may play a key role in inflammation-associated cancer.
S100A8 Related Studies
- Passey RJ, et al. (1999) S100A8: emerging functions and regulation. J Leukoc Biol. 66(4): 549-56.
- Gebhardt C, et al. (2006) S100A8 and S100A9 in inflammation and cancer. Biochem Pharmacol. 72(11): 1622-31.
- Halayko AJ, et al. (2009) S100A8/A9: a mediator of severe asthma pathogenesis and morbidity? Can J Physiol Pharmacol. 87(10): 743-55.
- Ghavami S, et al. (2009) S100A8/A9: a Janus-faced molecule in cancer therapy and tumorgenesis. Eur J Pharmacol. 625(1-3): 73-83.
- Ha YS, et al. (2010) mRNA Expression of S100A8 as a Prognostic Marker for Progression of Non-Muscle-Invasive Bladder Cancer. Korean J Urol. 51(1): 15-20.
