Anti-S100A8 Antibody

Cat: 11138-RP02
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Anti-S100A8 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-S100A8 Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human, Mouse, Rat
Specificity
Human S100A8
Immunogen
Recombinant Human S100A8 protein (Catalog#11138-H07E)
Preparation
Produced in rabbits immunized with purified, recombinant Human S100A8 (rh S100A8; Catalog#11138-H07E; NP_002955.2; Leu 2-Glu 93). S100A8 specific IgG was purified by human S100A8 affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-S100A8 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:5000-1:20000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-S100A8 Antibody (Rabbit Polyclonal antibody) Images
Human S100A8/MRP-8 Immunohistochemistry(IHC) 3646
Immunochemical staining of human S100A8 in human tonsil with rabbit polyclonal antibody (1:10000, formalin-fixed paraffin embedded sections).
Human S100A8/MRP-8 Immunohistochemistry(IHC) 3647
Immunochemical staining of human S100A8 in human spleen with rabbit polyclonal antibody (1:10000, formalin-fixed paraffin embedded sections).
Anti-S100A8 Antibody Alternative Names
Anti-60B8AG Antibody;Anti-CAGA Antibody;Anti-CFAG Antibody;Anti-CGLA Antibody;Anti-CP-10 Antibody;Anti-L1Ag Antibody;Anti-MA387 Antibody;Anti-MIF Antibody;Anti-MRP-8 Antibody;Anti-MRP8 Antibody;Anti-NIF Antibody;Anti-P8 Antibody
S100A8 Background Information

S100A8 is a member of the S100 protein family containing 2EF-hand calcium-binding motifs. S100 proteins are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. Altered expression of S100A8 protein is associated with various diseases and cancers. S100A8 may have an immunoregulatory role by contributing to the regulation of fetal-maternal interactions. It may play a protective role and its absence may allow infiltration by maternal cells, a process eventually manifesting as resorption. The heterodimeric S100 protein complex S100A8/A9 which has been shown to be involved in inflammatory and neoplastic disorders. The complex can induce cell proliferation, or apoptosis, inflammation, collagen synthesis, and cell migration. S100A8/A9 has emerged as important pro-inflammatory mediator in acute and chronic inflammation. More recently, increased S100A8 and S100A9 levels were also detected in various human cancers, presenting abundant expression in neoplastic tumor cells as well as infiltrating immune cells. On the one hand, S100A8/A9 is a powerful apoptotic agent produced by immune cells, making it a very fascinating tool in the battle against cancer. It spears the risk to induce auto-immune response and may serve as a lead compound for cancer-selective therapeutics. In contrast, S100A8/A9 expression in cancer cells has also been associated with tumor development, cancer invasion or metastasis. Altogether, its expression and potential cytokine-like function in inflammation and in cancer suggests that S100A8/A9 may play a key role in inflammation-associated cancer.

Full Name
S100 calcium binding protein A8
References
  • Passey RJ, et al. (1999) S100A8: emerging functions and regulation. J Leukoc Biol. 66(4): 549-56.
  • Gebhardt C, et al. (2006) S100A8 and S100A9 in inflammation and cancer. Biochem Pharmacol. 72(11): 1622-31.
  • Halayko AJ, et al. (2009) S100A8/A9: a mediator of severe asthma pathogenesis and morbidity? Can J Physiol Pharmacol. 87(10): 743-55.
  • Ghavami S, et al. (2009) S100A8/A9: a Janus-faced molecule in cancer therapy and tumorgenesis. Eur J Pharmacol. 625(1-3): 73-83.
  • Ha YS, et al. (2010) mRNA Expression of S100A8 as a Prognostic Marker for Progression of Non-Muscle-Invasive Bladder Cancer. Korean J Urol. 51(1): 15-20.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-S100A8 Antibody Rabbit Polyclonal ELISA 50228-RP01
    Anti-S100A8 Antibody Rabbit Polyclonal ELISA,IHC-P 50228-T24
    Anti-S100A8 Antibody Rabbit Monoclonal ELISA 50228-R008
    Anti-S100A8 Antibody Rabbit Polyclonal WB,ELISA,IHC-P,ICC/IF,IF 11138-T58
    Anti-S100A8 Antibody Rabbit Monoclonal IHC-P 11138-R101
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