S100A7 / PSOR1 Protein (Native)

S100 Calcium-Binding Protein A7 ( S100A7 / PSOR1 ) Protein

S100A7 / PSOR1 Protein Product Information

• Synonym: PSOR1, S100A7c
• Protein Construction: A DNA sequence encoding the native human S100A7 ( NP_002954.2 ) ( Met 1 - Gln 101 ) was expressed
• Source: Human
• Expression Host: E. coli

S100A7 / PSOR1 Protein QC Testing

• Purity: > 98 % as determined by SDS-PAGE
• Endotoxin: Please contact us for more information.
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Predicted N terminal: Met
• Molecular Mass: The recombinant human S100A7 consisting of 101 amino acids and migrates as an 11.6 kDa band in SDS-PAGE under reducing conditions as predicted
• Formulation: Lyophilized from sterile PBS , pH 7.4
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.
• SDS-PAGE: S100A7 protein

S100A7 / PSOR1 Protein Usage Guide

• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

S100A7 / PSOR1 Protein Description

Protein S100-A7, also known as S100 calcium-binding protein A7, Psoriasin, S100A7, and PSOR1, is a secreted protein which belongs to the S-100 family. S100A7 was first isolated from skin involved by psoriasis, which can be induced in cultured squamous epithelial cells. S100A7 is expressed by both normal cultured and malignant keratinocytes and malignant breast epithelial cells within ductal carcinoma in situ, suggesting an association with abnormal pathways of differentiation. S100A7 plays a role in the pathogenesis of inflammatory skin disease, as a chemotactic factor for hematopoietic cells. It also plays a role in early stages of breast tumor progression in association with the development of the invasive phenotype.

References

1. Miyasaki, KT. et al., 1993, J. Dent. Res. 72: 517-23.
2. Watson, PH. et al., 1998, Int J Biochem Cell Biol  30 (5):567-71.
3. Emberley, ED. et al., 2004, Breast Cancer Res  6 (4): 153-9.
4. Ohuchida, K. et al., 2006, Clin Cancer Res  12 (18):5417-22.
5. Kouno, T. et al., 2008, J Pept Sci. 14 (10):1129-38.
6. León, R. et al., 2009, Biochemistry. 48 (44): 10591-600.