S100A5

S100A5 binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites.

S100A5 Related Areas

Signal Transduction>>Calcium Signaling>>Calcium Binding Protein>>S100 Protein>>S100A5

S100A5 Alternative Names

S100A5, S100D [Homo sapiens]

S100A5, S100D9 [Mus musculus]

Summaries for S100A5

Entrez Gene summary for S100A5:

The protein encoded by S100A5 gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca2+ affinity 20- to 100-fold higher than the other S100 proteins studied under identical conditions. This protein also binds Zn2+ and Cu2+, and Cu2+ strongly which impairs the binding of Ca2+. This protein is expressed in very restricted regions of the adult brain. [provided by RefSeq, Jul 2008]

Wikipedia summary for S100A5:

Protein S100-A5 is a protein that in humans is encoded by the S100A5 gene.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca2+ affinity 20- to 100-fold higher than the other S100 proteins studied under identical conditions. This protein also binds Zn2+ and Cu2+, and Cu2+ strongly which impairs the binding of Ca2+. This protein is expressed in very restricted regions of the adult brain.

Human S100A5 Protein General Information

 

• Protein names: Protein S100-A5
  Short name=S100A5
• Sequence length: 92 AA.
• Domain: Repeat
• Sequence similarities: Belongs to the S-100 family.
  Contains 2 EF-hand domains.
• Sequence caution: The sequence CAA79472.1 differs from that shown. Reason: Erroneous initiation.
  The sequence CAA79475.1 differs from that shown. Reason: Erroneous initiation.
  The sequence CAA79479.1 differs from that shown. Reason: Erroneous initiation.
• Subunit structure: Homodimer.

General information above from UniProt

Function for S100A5 Protein

UniProtKB:

S100A5 binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites.

Genatlas:

• S100A5 plays an inherent functional role to the post-thick ascending limb of Henle portion in the nephron
• S100A5 has calcium ion binding activity.