S100A3

S100A3 binds both calcium and zinc. S100A3 probably binds 2 zinc ions per molecule. S100A3 may be involved in calcium-dependent cuticle cell differentiation and hair shaft formation.

S100A3 Related Areas

Signal Transduction>>Calcium Signaling>>Calcium Binding Protein>>S100 Protein>>S100A3/S100E

S100A3 Alternative Names

S100A3, S100E [Homo sapiens]

S100a3, S100E [Mus musculus]

Summaries for S100A3

Entrez Gene summary for S100A3:

The protein encoded by S100A3 gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown. [provided by RefSeq, Jul 2008]

Wikipedia summary for S100A3:

Protein S100-A3 is a protein that in humans is encoded by the S100A3 gene.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown.

Human S100A3 Protein General Information

 

• Protein names: Protein S100-A3
  Short name=S100A3
• Sequence length: 101 AA.
• Domain: Repeat
• Sequence similarities: Belongs to the S-100 family.
  Contains 2 EF-hand domains.
• Subunit structure: Homodimer.
• Tissue specificity: Skin specific.

General information above from UniProt

Function for S100A3 Protein

UniProtKB:

S100A3 binds both calcium and zinc. S100A3 probably binds 2 zinc ions per molecule. S100A3 may be involved in calcium-dependent cuticle cell differentiation and hair shaft formation.