Anti-S100A3 Antibody

Cat: 11136-RP02
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Anti-S100A3 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-S100A3 Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human S100A3
Immunogen
Recombinant Human S100A3 protein (Catalog#11136-H10E)
Preparation
Produced in rabbits immunized with purified, recombinant Human S100A3 (rh S100A3; Catalog#11136-H10E; P33764; Met 1-Gln 101). S100A3 specific IgG was purified by Human S100A3 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-S100A3 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:500-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-S100A3 Antibody (Rabbit Polyclonal antibody) Images
Human S100A3 Immunohistochemistry(IHC) 3660
Immunochemical staining of human S100A3 in human tonsil with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). The image showing positive staining in tonsil crypt.
Human S100A3 Immunohistochemistry(IHC) 3661
Immunochemical staining of human S100A3 in human skinl with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). The image showing positive staining in hair follicle and sebaceous gland.
Anti-S100A3 Antibody Alternative Names
Anti-S100E Antibody
S100A3 Background Information

Protein S100-A3, also known as Protein S-100E, S100 calcium-binding protein A3, S100A3 and S100E, is a member of the S-100 family. S100A3 / S100E contains 2 EF-hand domains. S100A3 / S100E is highly expressed in the differentiating cuticular cells within the hair follicle and organized into mature hair cuticles. High concentrations of S100A3 homotetramer might provide the millimolar level of Ca2+ required for hair cuticular barrier formation. S100A3 / S100E is a unique member of the Ca2+-binding S100 protein family with the highest cysteine content and affinity for Zn2+. S100A3 / S100E binds both calcium and zinc. S100A3 / S100E probably binds 2 zinc ions per molecule. It may be involved in calcium-dependent cuticle cell differentiation and hair shaft formation. S100A3 plays an important role in calcium-dependent processes leading to hair shaft formation. S100A3 / S100E is a unique protein among all members of the calcium-binding S100 family, is specifically expressed at the inner endocuticle of human hair fibers. Upon hair damage, S100A3 / S100E is released from hair fibers and possibly destabilizes the hair tissue architecture.

Full Name
S100 calcium binding protein A3
References
  • Kizawa, K. et al., 2008, J Biol Chem. 283 (8):5004-13.
  • Kizawa, K. et al., 1998, J Invest Dermatol. 111 (5):879-86.
  • Kizawa, K. et al., 2002, Biochem Biophys Res Commun. 299 (5):857-62.
  • Fritz,G. et al., 2002, J Biol Chem. 277 (36):33092-8.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-S100A3 Antibody Rabbit Polyclonal ELISA 50428-RP01
    Anti-S100A3 Antibody Rabbit Monoclonal ELISA 50428-R001
    Anti-S100A3 Antibody Rabbit Polyclonal WB,ELISA 50428-T48
    Anti-S100A3 Antibody Mouse Monoclonal ELISA 11136-MM05
    Anti-S100A3 Antibody Rabbit Polyclonal ELISA 11136-RP01
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