S100A2 Protein (Native)

Calcium-Binding Protein S100A2 / S100A2 / CAN19 Protein Datasheet

S100A2 / CAN19 Protein Product Information

• Synonym: RP11-49N14.8, CAN19, MGC111539, S100L
• Protein Construction: A DNA sequence encoding the human S100A2 (NP_005969.1) (Met 2- Pro 98 ) was expressed
• Source: Human
• Expression Host: E.coli

S100A2 / CAN19 Protein QC Testing

• Purity: > 95% as determined by SDS-PAGE
• Endotoxin: Please contact us for more information.
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Predicted N terminal: Met 2
• Molecular Mass: The recombinant human S100A2 consists of 97 amino acids and has a predicted molecular mass of 11 KDa
• Formulation: Lyophilized from sterile PBS , pH 7.4
• SDS-PAGE:

S100A2 / CAN19 Protein Usage Guide

• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

S100A2 / CAN19 Protein Description

The calcium-binding Protein S100A2 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 family genes are located as a cluster on chromosome 1q21, and S100 proteins consisting of at least 20 members are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation. S100A2 was first detected in lung and kidney, and is mainly expressed in a subset of tissues and cells such as breast epithelia and liver. The S100A2 protein is a homodimer that undergoes a conformational change upon binding of calcium, and the active form functions in regulating cell proliferation and differentiation, gene transcription, and p53-dependent growth arrest and apoptosis. Accordingly, this protein is regarded as a putative tumor suppressor, and thus chromosomal rearrangements and reduced expression of S100A2 gene have been implicated in certain carcinomas.

References

1. Gimona, M. et al., 1997, J. Cell. Sci. 110: 611-621.
2. Mueller, A. et al., 2005, J. Biol. Chem. 280: 29186-29193.
3. Lapi, E. et al., 2006, Oncogene. 25: 3628-3637.
4. Feng, G. et al., 2001, Cancer. Res. 61: 7999-8004.
5. Gupta, S. et al., 2003, J. Clin. Oncol. 21: 106-112.