S100A16 cDNA ORF Clone in Cloning Vector, Rat

Cat: RG80736-U
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S100A16 cDNA ORF Clone in Cloning Vector, Rat General Information
Gene
Species
Rat
NCBI Ref Seq
RefSeq ORF Size
372 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Rat S100 calcium binding protein A16.
Plasmid
Vector
pUC19 Vector
Sequencing Primers
M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
S100A16 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

S100A16 cDNA ORF Clone in Cloning Vector, Rat Validated Images
Cynomolgus GEMIN8 Gene Plasmid Map 7146
S100A16 Background Information

S100A16 is a member of S100 protein super family that carries calcium-binding EF-hand motifs. S100 proteins are cell- and tissue-specific and are involved in many intra- and extracellular processes through interacting with specific target proteins. S100A16 expression was found to be astrocyte-specific. The S100A16 protein was found to accumulate within nucleoli and to translocate to the cytoplasm in response to Ca(2+) stimulation. The homodimeric structure of human S100A16 in the apo state has been obtained both in the solid state and in solution, resulting in good agreement between the structures with the exception of two loop regions. The homodimeric solution structure of human S100A16 was also calculated in the calcium(II)-bound form. Differently from most S100 proteins, the conformational rearrangement upon calcium binding is minor. Immunoprecipitation analysis revealed that S100A16 could physically interact with tumor suppressor protein p53, also a known inhibitor of adipogenesis. Overexpression or RNA interference-initiated reduction of S100A16 led to the inhibition or activation of the expression of p53-responsive genes, respectively. S100A16 protein is a novel adipogenesis-promoting factor.

Full Name
S100 calcium binding protein A16
References
  • Sturchler E, et al. (2006) S100A16, a novel calcium-binding protein of the EF-hand superfamily. J Biol Chem. 281(50): 38905-17.
  • Liu Y, et al. (2011) Identification of S100A16 as a Novel Adipogenesis Promoting Factor in 3T3-L1 Cells. Endocrinology. 152(3): 903-11.
  • Babini E, et al. (2011) Structural characterization of human S100A16, a low-affinity calcium binder. J Biol Inorg Chem. 16(2): 243-56.
  • S100A16 cDNA ORF Clone, Rat, Related Products

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    S100A16 cDNA ORF Clone, Rat, untagged RG80736-UT
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    S100A16 cDNA ORF Clone, Rat, C-His tag RG80736-CH
    S100A16 cDNA ORF Clone, Rat, N-His tag RG80736-NH
    S100A16 cDNA ORF Clone, Rat, C-HA tag RG80736-CY
    S100A16 cDNA ORF Clone, Rat, N-HA tag RG80736-NY
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    S100A16 cDNA ORF Clone, Mouse, Related Products

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    S100A16 cDNA ORF Clone in Cloning Vector, Mouse MG51916-U
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    S100A16 cDNA ORF Clone, Mouse, C-GFPSpark® tag MG51916-ACG
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    S100A16 cDNA ORF Clone, Mouse, C-His tag MG51916-CH
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    S100A16 cDNA ORF Clone, Mouse, N-HA tag MG51916-NY
    S100A16 cDNA ORF Clone, Mouse, C-Myc tag MG51916-CM
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    S100A16 cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    S100A16 cDNA ORF Clone in Cloning Vector, Human HG11137-U
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    S100A16 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG11137-CF
    S100A16 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG11137-NF
    S100A16 cDNA ORF Clone, Human, C-His tag HG11137-CH
    S100A16 cDNA ORF Clone, Human, N-His tag HG11137-NH
    S100A16 cDNA ORF Clone, Human, C-HA tag HG11137-CY
    S100A16 cDNA ORF Clone, Human, N-HA tag HG11137-NY
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