S100A15 / S100A7A Protein Price Inquiry ( Available Sizes )
S100A15 / S100A7A Protein Product Information
||A DNA sequence encoding the mouse S100A7A (Q6S5I3) (Met 1 –Tyr 108) was fused with the N-terminal polyhistidine-tagged MBP tag at the N-terminus.
S100A15 / S100A7A Protein QC Testing
||> 90 % as determined by SDS-PAGE.
S100A15 / S100A7A protein
||Please contact us for more information.
||Samples are stable for up to twelve months from date of receipt at -70℃
|Predicted N terminal:
||The recombinant mouse S100A7A/MBP fusion protein consists of 505 amino acids and has a calculated molecular mass of 56.5 KDa. It migrates as an approximately 50kDa band in SDS-PAGE under reducing conditions.
||Lyophilized from sterile PBS, pH7.5
- Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
- Please contact us for any concerns or special requirements.
S100A15 / S100A7A Protein Usage Guide
||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
S100A15 / S100A7A Protein Related Products & Topics
S100A15 / S100A7A Protein Description
Protein S100-A7, also known as S100 calcium-binding protein A7, Psoriasin, S100A7, and PSOR1, is a secreted protein which belongs to the S-100 family. S100A7 was first isolated from skin involved by psoriasis, which can be induced in cultured squamous epithelial cells. S100A7 is expressed by both normal cultured and malignant keratinocytes and malignant breast epithelial cells within ductal carcinoma in situ, suggesting an association with abnormal pathways of differentiation. S100A7 plays a role in the pathogenesis of inflammatory skin disease, as a chemotactic factor for hematopoietic cells. It also plays a role in early stages of breast tumor progression in association with the development of the invasive phenotype. Protein S100-A7A (S100A7A) or S100 calcium-binding protein A15 (S100A15) is is almost identical to hS100A7 and difficult to discriminate. Human S100A7A/S100A15 is a novel member of the S100 family of EF-hand calcium-binding proteins and was recently identified in psoriasis, where it is significantly upregulated in lesional skin. Although its biological function is unclear, the association of the 11.2 kDa S100A7A/S100A15 with psoriasis suggests that it contributes to the pathogenesis of the disease and could provide a molecular target for therapy.
- Wolf R. et al., 2009, Cancer Lett. 277 (1): 101-7.
- Büchau AS. et al., 2007, J Invest Dermatol. 127 (11): 2596-604.
- Boeshans KM. et al., 2006, Acta Crystallogr Sect F Struct Biol Cryst Commun. 62 (5): 467-70.