S100A12

Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus. S100A12 binds calcium, zinc and copper. Presence of zinc increases the affinity for calcium. S100A12 plays an important role in the inflammatory response. S100A12 interaction with AGER on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators.

S100A12 Related Areas

Neuroscience>>Neurotrophic Factor & Receptor>>Other Neurotrophic Factors & Receptors>>S100A12

Signal Transduction>>Calcium Signaling>>Calcium Binding Protein>>S100 Protein>>S100A12

S100A12 Alternative Names

S100A12, CAAF1, CAGC, CGRP, ENRAGE, MRP6, p6, EN-RAGE [Homo sapiens]

Summaries for S100A12

Entrez Gene summary for S100A12:

The protein encoded by this S100A12 gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. S100A12 is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. [provided by RefSeq, Jul 2008]

Wikipedia summary for S100A12:

Protein S100-A12 is a protein that in humans is encoded by the S100A12 gene.

Human S100A12 Protein General Information

 

• Protein names: S100 calcium-binding protein A12
• Sequence length: 92 AA.
• Sequence similarities: S100A12 belongs to the S-101 family. S100A12 contains 2 EF-hand domains.
• Subunit structure: Homodimer. Homooligomer (tetramer or hexamer) in the presence of calcium and zinc ions. Interacts with AGER and both calcium and zinc are essential for the interaction.
• Mass spectrometry: Molecular mass is 10444 Da from positions 2 - 92. Determined by ESI.
  Molecular mass is 1688.9 Da from positions 78 - 92. Determined by MALDI.
• Tissue specificity: Monocytes and lymphocytes.

General information above from UniProt

Function for S100A12 Protein

UniProtKB:

Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus. S100A12 binds calcium, zinc and copper. Presence of zinc increases the affinity for calcium. S100A12 plays an important role in the inflammatory response. S100A12 interaction with AGER on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators.

Genatlas:

• S100A12 may be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities
• specific calcium dependent signal transduction
• S100A12 is potent monocyte chemoattractant involved in the regulation of neutrophils activation
• S100A12 plays a role in the pathogenesis of inflammatory bowel disease
• S100A12 may have a chaperone/antichaperone-like function which is Ca2+-dependent
• S100A12 may be involved in the pathophysiology of acute vasculitis (Kawasaki disease)

Homology for human S100A12

• homolog to S100A9