Anti-S100A10 Antibody

Cat: 11144-RP02

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Anti-S100A10 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-S100A10 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human S100A10
Recombinant Human S100A10 protein (Catalog#11144-H07E)
Produced in rabbits immunized with purified, recombinant Human S100A10 (rh S100A10; Catalog#11144-H07E; NP_002957.1; Pro 2-Lys 97). S100A10 specific IgG was purified by Human S100A10 affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-S100A10 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:1000  
ELISA 1:25000-1:50000  
IHC-P 1:2500-1:15000  
IP 0.2-1 μL/mg of lysate  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-S100A10 Antibody (Rabbit Polyclonal antibody) Images
Human S100A10 Immunohistochemistry(IHC) 3667
Immunochemical staining of human S100A10 in human renal carcinoma with rabbit polyclonal antibody at 1:10000 dilution, formalin-fixed paraffin embedded sections.
Human S100A10 Immunohistochemistry(IHC) 3671
Immunochemical staining of human S100A10 in human breast carcinoma with rabbit polyclonal antibody at 1:10000 dilution, formalin-fixed paraffin embedded sections.
Human S100A10 Immunoprecipitation(IP) 8058

S100A10 was immunoprecipitated using:

Lane A:0.5 mg A431 Whole Cell Lysate

0.5 µL anti-S100A10 rabbit polyclonal antibody and 15 μl of 50 % Protein G agarose.

Primary antibody:

Anti-S100A10 rabbit polyclonal antibody,at 1:1000 dilution

Secondary antibody:

Dylight 800-labeled antibody to rabbit IgG (H+L), at 1:5000 dilution

Developed using the odssey technique.

Performed under reducing conditions.

Predicted band size: 11 kDa

Observed band size: 11 kDa

Human S100A10 Western blot (WB) 13352

Anti-S100A10 rabbit polyclonal antibody at 1:500 dilution

Lane A: A431 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.


Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:11 kDa

Observed band size:11 kDa

Anti-S100A10 Antibody Alternative Names
Anti-42C Antibody;Anti-ANX2L Antibody;Anti-ANX2LG Antibody;Anti-CAL1L Antibody;Anti-Ca[1] Antibody;Anti-CLP11 Antibody;Anti-GP11 Antibody;Anti-MGC111133 Antibody;Anti-p10 Antibody;Anti-P11 Antibody
S100A10 Background Information

S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of intracellular and extracellular functions. They are involved in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response.  
Protein S100-A10, also known as Calpactin I light chain, Cellular ligand of annexin II, S100 calcium-binding protein A10, p10 protein, p11, ANX2LG and S100A10, is a member of the S100 family of small, dimeric EF hand-type Ca(2+)-binding proteins that generally modulate cellular target proteins in response to intracellular Ca(2+) signals. In contrast to all other S100 proteins, S100A10 is Ca(2+) insensitive because of amino acid replacements in its Ca(2+)-binding loops that lock the protein in a permanently active state. S100A10 forms a heterotetramer with annexin IIH and promotes carcinoma invasion and metastasis by plasminogen activation. S100A10 and annexin II contribute to the aggressive characteristics of anaplastic carcinoma, while playing a constitutive role in papillary carcinoma. S100A10 induces the dimerization of ANXA2 / p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target of tyrosine-specific kinase. S100A10 functions as a linker tethering certain transmembrane proteins to annexin A2 thereby assisting their traffic to the plasma membrane and/or their firm anchorage at certain membrane sites.

Full Name
S100 calcium binding protein A10
  • Gebhardt, C. et al., 2006, Biochem Pharmacol. 72 (11):1622-31.
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  • Nonaka, D. et al., 2008, J. Cutan. Pathol. 35 (11): 1014-9.
  • Lim, SY. et al., 2008,  J Immunol. 181 (8): 5627-36.
  • Heibeck TH. et al., 2009, J. Proteome Res. 8:3852-61.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-S100A10 Antibody Rabbit Polyclonal ELISA 11144-RP01
    Anti-S100A10 Antibody Mouse Monoclonal IHC-P 11144-MM03
    Anti-S100A10 Antibody Rabbit Polyclonal ELISA,IHC-P,IP 11144-T28
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