- EGFR Signaling Pathway
- TGF-beta Signaling
- Canonical Wnt Signaling
- non-Canonical Wnt Signaling
- Notch Signaling
- p53 Pathway
- NF-kB Pathway
- Cytokine Signaling
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S100A1 Antibody ( Antigen Affinity Purified ) Datasheet
|Order or Inquire for S100A1 Antibody product||Quality antibodies||Antibody production services|
|Detection limit is 0.00975 ng/well in ELISA|
S100A1 Antibody Product Information
Recombinant Mouse S100A1 protein (Catalog#50266-M07E)
|Antibody Type :||Rabbit Polyclonal Antibody ( Antibody Purification Platform )|
|Ig Type :||
|Formulation :||0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.|
Produced in rabbits immunized with purified, recombinant Mouse S100A1 (rM S100A1; Catalog#50266-M07E; P56565; Gly 2-Ser 94). S100A1 specific IgG was purified by Mouse S100A1 affinity chromatography.
S100A1 Antibody Usage Guide
IHC-P: 0.1-2 μg/mL
|Direct ELISA :||This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse S100A1. The detection limit for Mouse S100A1 is approximately 0.00975 ng/well.|
|Storage :||This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
S100A1 Antibody Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|S100A1||Human||S100A1/Fc Protein, Recombinant||10179-H01H|
|S100A1||Human||S100A1 Protein, Recombinant||10179-HNAE|
|S100A1||Mouse||S100A1 Protein, Recombinant||50266-M07E|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|Mouse S100A1||ELISA, IHC-P||S100A1 Antibody (Antigen Affinity Purified)||50266-RP02|
S100A1 Antibody Background
S100A1 is a Ca2+ binding protein of the EF-hand type that belongs to the S100 protein family. S100 proteins consisting of at least 19 members exist as dimers in the cytoplasm and/or nucleus of a wide range of cells, and are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation. This protein has been shown to function in the processes including stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of PKC-mediated phosphorylation.. Phosphoglucomutase is a target protein whose activity is antagonistically regulated by S100A1, and recently, S100A1 is also identified as a potent molecular chaperone and a new member of the Hsp70/Hsp90 multichaperone complex. S100A1 displays a tissue-specific expression pattern with highest levels in myocardium and is considered to be an important regulator of cardiac contractility. Accordingly, reduced expression or mutations of S100A1 gene have been implicated in cardiomyopathies.
- Remppis, A.et al., 1996, Biochim. Biophs. Acta. 1313: 253-257.
- Most, P. et al., 2001, Proc. Natl. Acad. Sci. U.S.A. 98: 13889-13894.
- Okada, M. et al., 2004, J. Biol. Chem. 279: 4221-4233.
- Schafer, W.E. et al., 1995, Genomics. 25: 638-643.
- Landar, A. et al., 1996, Cell. Calcium. 20: 279-285.