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S100 Protein

Sino Biological offers a comprehensive set of tools for research on S100 protein family, including recombinant proteins, antibodies (rabbit mAbs, mouse mAbs, rabbit pAbs), ELISA kits, and ORF cDNA clones. The s100 proteins within cells have been implicated in protein phosphorylation, etc. While the extracellular s100 proteins can effect the activity of inflammatory cells. Members of s100 family have been used as the marker for certain tumors and epidermal differentiation inflammatory diseases.

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    S100 Protein Background

    S100 family is kind of EF-hand protein differing from the ubiquitous calcium binding protein, which is cell-specific and expressed in certain cells depending on environment factors . There are at least 21 different types of S100 family. Most S100 proteins are homodimeric, consisting of two identical polypeptides held together by non-covalent bonds. Within cells, S100 proteins have been involved in the regulation of protein phosphorylation, the dynamics of cytoskeleton components, etc. Certain S100 members are released into the extracellular space. Extracellular S100 proteins stimulate neuronal survival and/or differentiation and astrocyte proliferation, causeing neuronal death via apoptosis, and effect the activity of inflammatory cells. S100 proteins have been used in the lab as cell markers for anatomic pathology. Several members of the S100 family are useful as markers for certain tumors and epidermal differentiation. It can be found in melanomas, 50% of malignant peripheral nerve sheath tumors, etc. Further, members of S100 proteins, such as S100A7 and S100A15,are markers for inflammatory diseases and can mediate inflammation and act as antimicrobials.

    S100 Protein References

    1. Donato R, (2001) S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellutar functional foles. The international Journal of biochemistry and cell biology. 33(7): 637-68.
    2. Beat W, et al. (1996) The S100 family of EF-hand calcium-binding proteins: functions and pathology. Trends in biochemical sciences. 21(4): 134-40.
    3. Donato R, (2003) Intracellular and extracellular roles of S100 proteins. Microsc Res Tech. 60(6): 540–51.
    4. Wolf R, et al. (2008) Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15. J Immunol 181 (2): 1499-506.