RNase A (Ribonuclease A, RNASE1)

RNase A, also known as ribonuclease A and RNASE1, belongs to ribonuclease A superfamily. It is a pancreatic-type of secretory ribonuclease. RNase A is a basic protein and its many positive charges are consistent with its binding to RNA (a poly-anion). More generally, RNase A is unusually polar or, rather, unusually lacking in hydrophobic groups, especially aliphatic ones. As a endonuclease, RNase A cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. RNase A is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.

RNase A Related Areas

 

RNase A (Ribonuclease A, RNASE1) Alternative Names

RIB1, RNS1, HP-RNase, RIB-1, RNase 1, RNase A, RNase upI-1, ribonuclease 1, ribonuclease A, ribonuclease pancreatic [Homo sapiens]

AI574248, Rib-1, Rib1, RNase 1, RNase A, ribonuclease 1, pancreatic, ribonuclease pancreatic [Mus musculus]

Summaries for RNase A (Ribonuclease A, RNASE1)

Entrez Gene summary for RNASE1:

This RNASE1 gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. RNASE1 prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

OMIM - description for RNase A:

Pancreatic ribonuclease (RNase A)(EC 3.1.27.5) is one of the digestive enzymes secreted in abundance by the pancreas.

Wikipedia summary for RNase A:

Ribonuclease A (RNase A) is a pancreatic ribonuclease that cleaves single-stranded RNA. Bovine pancreatic RNase A is one of the classic model systems of protein science.

Human RNase A (Ribonuclease A, RNASE1) Protein General Information

 

• Protein names: Ribonuclease A, Short name=RNase A
• Sequence length: 156 AA.
• Catalytic activity: Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates.
• Sequence similarities: RNase A belongs to the pancreatic ribonuclease family.
• Post-translational modification: N-linked glycans are of complex type.
• Subunit structure: Monomer. RNase A interacts with and forms tight 1:1 complexes with RNH1. Dimerization of two such complexes may occur. Interaction with RNH1 inhibits this protein.
• Subcellular location: Secreted.
• Tissue specificity: Pancreas and other tissues and body fluids (indicating it may have other physiological functions besides its role in digestion).

General information above from UniProt

Function for RNase A (Ribonuclease A, RNASE1) Protein

UniProtKB:

RNase A is endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. RNase A acts on single stranded and double stranded RNA.

Genatlas:

• RNase A is involved in vascular homeostasis