Anti-RhoA Antibody

Cat: 12441-R101
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Anti-RhoA Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-RhoA Antibody
Validated applications
Species reactivity
Reacts with: Human
Human RhoA
Recombinant Human RhoA protein (Catalog#12441-H07B)
This antibody was obtained from a rabbit immunized with purified, recombinant Human RhoA (rh RhoA; Catalog#12441-H07B; P61586-1; Met1-Leu193).
Monoclonal Rabbit IgG Clone #101
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-RhoA Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-RhoA Antibody Alternative Names
Anti-ARH12 Antibody;Anti-ARHA Antibody;Anti-RHO12 Antibody;Anti-RHOH12 Antibody
RhoA Background Information

Transforming protein RhoA, also known as Rho cDNA clone 12, Ras homolog gene family member A, RHOA and ARH12, is a cell membrane and cytoplasm protein which belongs to the small GTPase superfamily and Rho family. The Rho family of small GTPases plays a key role in the dynamic regulation of the actin cytoskeleton that underlies various important cellular functions such as shape changes, migration, and polarity. RHOA / ARH12 is part of a larger family of related proteins known as the Ras superfamily; proteins involved in the regulation and timing of cell division. RHOA / ARH12 is a small GTPase protein known to regulate the actin cytoskeleton in the formation of stress fibers. It acts upon two known effector proteins: ROCK1 (Rho-associated, coiled-coil containing protein kinase 1) and DIAPH1 ( diaphanous homolog 1 (Drosophila) ). RHOA / ARH12 regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. RHOA / ARH12 serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. RHOA / ARH12 may be an activator of PLCE1. It is activated by ARHGEF2, which promotes the exchange of GDP for GTP.

Full Name
ras homolog family member A
  • Kiss C, et al.,1997, Cytogenet. Cell Genet. 79 (3-4): 228-30.
  • Anastasiadis,P.Z. et al., 2000, Nat Cell Biol. 2 (9):637-44.
  • Yiu G, et al.,2006, Nat. Rev. Neurosci. 7 (8): 617-27.
  • Wang,HR. et al., 2006, Methods Enzymol. 406 :437-47.
  • Heo,J. et al., 2006, Biochemistry. 45 (48):14481-9.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-RhoA Antibody (FITC) Rabbit Monoclonal FCM 12441-R036-F
    Anti-RhoA Antibody Rabbit Polyclonal WB,ELISA,IP 12441-RP02
    Anti-RhoA Antibody (FITC) Mouse Monoclonal FCM 12441-MM03-F
    Anti-RhoA Antibody (PE) Mouse Monoclonal FCM 12441-MM03-P
    Anti-RhoA Antibody Mouse Monoclonal ELISA 12441-MM09
    Anti-RhoA Antibody Rabbit Monoclonal FCM 12441-R036
    Anti-RhoA Antibody Mouse Monoclonal ELISA,FCM,ICC/IF,IF 12441-MM03
    Anti-RhoA Antibody Rabbit Monoclonal WB,IP 12441-R103
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