Renin

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

Renin Related Areas

Cardiovascular>>Blood Pressure Regulation>>Renin/REN

Enzyme>>Protease & Regulator>>Aspartate Protease & Regulator>>Renin/REN

Renin Alternative Names

Renin, REN, FLJ10761, HNFJ2

Summaries for Renin

Entrez Gene summary for REN:

Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin , an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]

OMIM - description for Renin:

Released by the juxtaglomerular cells of the kidney, renin (EC 3.4.23.15) catalyzes the first step in the activation pathway of angiotensinogen, a cascade that can result in aldosterone release, vasoconstriction, and increase in blood pressure. Renin cleaves angiotensinogen to form angiotensin I (106150), which is converted to angiotensin II by angiotensin I-converting enzyme (106180), an important regulator of blood pressure and electrolyte balance. Renin occurs in other organs than the kidney, e.g., in the brain, where it is implicated in the regulation of numerous activities.

Wikipedia summary for Renin:

Renin , also known as an angiotensinogenase, is an enzyme that participates in the body's renin-angiotensin system (RAS)—also known as the renin-angiotensin-aldosterone axis—that mediates extracellular volume (i.e., that of the blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. Thus, it regulates the body's mean arterial blood pressure.

Human Renin Protein General Information

 

• Protein names: Renin
• Sequence length: 406 AA.
• Catalytic activity: Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.
• Sequence similarities: Renin 1 belongs to the peptidase A1 family.
• Enzyme regulation: Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing.
• Subunit structure: Renin 1 interacts with ATP6AP2.
• Subcellular location: Secreted. Membrane. Note: Associated to membranes via binding to ATP6AP2.
• Tissue specificity: Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
• Biophysicochemical properties: Kinetic parameters:
  KM=1 µM for angiotensinogen (in absence of ATP6AP2)
  KM=0.15 µM for angiotensinogen (in presence of membrane-bound ATP6AP2)

General information above from UniProt

Function for Renin Protein

UniProtKB:

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

Genatlas:

• aspartic endopeptidase, angiotensin-forming enzyme, converting angiotensinogen to angiotensin I
• Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure
• primary function of renin is the hydrolytic cleavage of angiotensinogen to angiotensin, with the subsequent stimulation of aldosterone production (Zivna 2009)

Phenotype Information for Renin

• Gene/Locus: REN, HNFJ2
• Phenotype: Hyperuricemic nephropathy, familial juvenile 2
  Renal tubular dysgenesis
  [Hyperproreninemia]

Phenotype Information for Renin from OMIM (Online Mendelian Inheritance in Man)

Drugs for Renin

Target	Drug Name	Disease	Drug Status
Renin 1	Aliskiren	Hypertension	Approved
Renin 1	Remikiren	Hypertension	Approved

Drugs for Renin from TTD (Therapeutic Targets Database)