Anti-Renin Antibody

Cat: 10969-R009
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Anti-Renin Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-Renin Antibody
Validated applications
Species reactivity
Reacts with: Human
Human Renin
Has 20 % cross activity in ELISA with Mouse REN1 / Renin-1
Recombinant Human Renin protein (Catalog#10969-H08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Human Renin (rh Renin; Catalog#10969-H08H; NP_000528.1; Met 1-Arg 406).
Monoclonal Rabbit IgG Clone #009
Protein A
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Renin Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:1000  
ELISA 1:25000-1:50000  
IHC-P 1:500-1:2000  
ICC-IF 1:100-1:500  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Renin Antibody (Rabbit Monoclonal antibody) Images
Human Renin Immunofluorescence(IF) 2866
Immunofluorescence staining of Human Renin in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human Renin monoclonal antibody (1:300) at 37℃ 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to cytoplasm.
Human Renin Immunohistochemistry(IHC) 3689
Immunochemical staining of human RENIN in human kidney with rabbit monoclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.
Human Renin Western blot (WB) 13309

Anti-RENIN rabbit monoclonal antibody at 1:500 dilution

Lane A: K562 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.


Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:45 kDa

Observed band size:57 kDa

(We are unsure as to the identity of these extra bands.)

Anti-Renin Antibody Alternative Names
Anti-FLJ10761 Antibody;Anti-HNFJ2 Antibody;Anti-REN Antibody
Renin Background Information

Renin-1, also known as Ren-1, Angiotensinogenase and Kidney renin, is a member of the peptidase A1 family. Renin-1 is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sodium concentration. androgen and thyroid hormones influence levels of Renin-1 in mouse submandibular gland (SMG) primarily by regulating the amount of Renin-1 mRNA available for translation. Renin-1 is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. It is expressed at relatively low levels in mouse SMG and kidney. Ren-2 is expressed at high levels in the mouse SMG and at very low levels, if at all, in the kidney. Ren-1 and Ren-2 are closely linked on mouse chromosome 1, show extensive homology in coding and noncoding regions and provide a model for studying the regulation of gene expression.

Full Name
  • McKeon F.D., et al.,(1986), Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins. Nature 319:463-468.
  • Fisher D.Z., et al., (1986), cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins.Proc. Natl. Acad. Sci. U.S.A. 83:6450-6454.
  • Sylvius N., et al.,(2005), In vivo and in vitro examination of the functional significances of novel lamin gene mutations in heart failure patients.J. Med. Genet. 42:639-647.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Renin Antibody Rabbit Monoclonal ELISA,IHC-P 50279-R001
    Anti-Renin Antibody Rabbit Polyclonal ELISA,IHC-P 50279-RP02
    Anti-Renin Antibody Rabbit Polyclonal ELISA 50279-RP01
    Anti-Renin Antibody Mouse Monoclonal ELISA,IHC-P 10969-MM01
    Anti-Renin Antibody Mouse Monoclonal IHC-P 10969-MM04
    Anti-Renin Antibody Rabbit Polyclonal ELISA 10969-RP01
    Anti-Renin Antibody Rabbit Polyclonal ELISA 10969-RP02
    Anti-Renin Antibody Rabbit Polyclonal ELISA,IHC-P 10969-T24
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