Anti-Renin Antibody

Cat: 10969-MM01
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Anti-Renin Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-Renin Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human Renin
Immunogen
Recombinant Human Renin protein (Catalog#10969-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Renin (rh Renin; Catalog#10969-H08H; NP_000528.1; Met 1-Arg 406). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG2b Clone #3E2B11C4
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Renin Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  
IHC-P 1:50-1:200  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Renin Antibody (Mouse Monoclonal antibody) Images
Human Renin Immunohistochemistry(IHC) 3687
Immunochemical staining of human RENIN in human kidney (from 2 donors) with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections).
Anti-Renin Antibody Alternative Names
Anti-FLJ10761 Antibody;Anti-HNFJ2 Antibody;Anti-REN Antibody
Renin Background Information

Renin-1, also known as Ren-1, Angiotensinogenase and Kidney renin, is a member of the peptidase A1 family. Renin-1 is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sodium concentration. androgen and thyroid hormones influence levels of Renin-1 in mouse submandibular gland (SMG) primarily by regulating the amount of Renin-1 mRNA available for translation. Renin-1 is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. It is expressed at relatively low levels in mouse SMG and kidney. Ren-2 is expressed at high levels in the mouse SMG and at very low levels, if at all, in the kidney. Ren-1 and Ren-2 are closely linked on mouse chromosome 1, show extensive homology in coding and noncoding regions and provide a model for studying the regulation of gene expression.

Full Name
renin
References
  • McKeon F.D., et al.,(1986), Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins. Nature 319:463-468.
  • Fisher D.Z., et al., (1986), cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins.Proc. Natl. Acad. Sci. U.S.A. 83:6450-6454.
  • Sylvius N., et al.,(2005), In vivo and in vitro examination of the functional significances of novel lamin gene mutations in heart failure patients.J. Med. Genet. 42:639-647.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Renin Antibody Rabbit Monoclonal ELISA,IHC-P 50279-R001
    Anti-Renin Antibody Rabbit Polyclonal ELISA,IHC-P 50279-RP02
    Anti-Renin Antibody Rabbit Polyclonal ELISA 50279-RP01
    Anti-Renin Antibody Mouse Monoclonal IHC-P 10969-MM04
    Anti-Renin Antibody Rabbit Monoclonal WB,ELISA,IHC-P,ICC/IF,IF 10969-R009
    Anti-Renin Antibody Rabbit Polyclonal ELISA 10969-RP01
    Anti-Renin Antibody Rabbit Polyclonal ELISA 10969-RP02
    Anti-Renin Antibody Rabbit Polyclonal ELISA,IHC-P 10969-T24
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