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Renin / REN Antibody, Mouse MAb

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Human RENIN Antibody Product Information
Immunogen:Recombinant Human Renin protein (Catalog#10969-H08H)
Clone ID:3E2B11C4
Ig Type:Mouse IgG2b
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Renin (rh Renin; Catalog#10969-H08H; NP_000528.1; Met 1-Arg 406). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Human RENIN Antibody Usage Guide
Specificity:Human Renin / REN
No cross-reactivity with Human cell lysate (293 cell line) in WB and ELISA.
Application:ELISA, IHC-P

ELISA: 0.5-1 μg/mL

This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human RENIN. The detection limit for Human RENIN is 0.078 ng/well.

IHC-P: 10-30 μg/mL

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human RENIN Antibody IHC Application Image
ADAM15 / MDC15 Antibody, Rabbit MAb, Immunohistochemistry
[Click to enlarge image]
Immunohistochemical staining of formalin fixed, paraffin-embedded human lymphonode showing membrane staining of endothelial cells (red arrow) (0.5 μg/mL).
Renin / REN Antibody, Mouse MAb, Immunohistochemistry
[Click to enlarge image]
Immunochemical staining of human RENIN in human kidney (from 2 donors) with mouse monoclonal antibody (15 µg/mL, formalin-fixed paraffin embedded sections).
Other RENIN Antibody Products
Renin Background

Mouse Renin-1, also known as Ren-1, Angiotensinogenase and Kidney renin, is a member of the peptidase A1 family. Renin-1 is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sodium concentration. androgen and thyroid hormones influence levels of Renin-1 in mouse submandibular gland (SMG) primarily by regulating the amount of Renin-1 mRNA available for translation. Renin-1 is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. It is expressed at relatively low levels in mouse SMG and kidney. Ren-2 is expressed at high levels in the mouse SMG and at very low levels, if at all, in the kidney. Ren-1 and Ren-2 are closely linked on mouse chromosome 1, show extensive homology in coding and noncoding regions and provide a model for studying the regulation of gene expression.

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