Anti-Renin Antibody

Cat: 10969-MM01
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Anti-Renin Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-Renin Antibody
Validated applications
Species reactivity
Reacts with: Human
Human Renin
Recombinant Human Renin protein (Catalog#10969-H08H)
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Renin (rh Renin; Catalog#10969-H08H; NP_000528.1; Met 1-Arg 406). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Monoclonal Mouse IgG2b Clone #3E2B11C4
Protein A
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Renin Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  
IHC-P 1:50-1:200  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Renin Antibody (Mouse Monoclonal antibody) Images
Human Renin Immunohistochemistry(IHC) 3687
Immunochemical staining of human RENIN in human kidney (from 2 donors) with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections).
Anti-Renin Antibody Alternative Names
Anti-FLJ10761 Antibody;Anti-HNFJ2 Antibody;Anti-REN Antibody
Renin Background Information

Renin-1, also known as Ren-1, Angiotensinogenase and Kidney renin, is a member of the peptidase A1 family. Renin-1 is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sodium concentration. androgen and thyroid hormones influence levels of Renin-1 in mouse submandibular gland (SMG) primarily by regulating the amount of Renin-1 mRNA available for translation. Renin-1 is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. It is expressed at relatively low levels in mouse SMG and kidney. Ren-2 is expressed at high levels in the mouse SMG and at very low levels, if at all, in the kidney. Ren-1 and Ren-2 are closely linked on mouse chromosome 1, show extensive homology in coding and noncoding regions and provide a model for studying the regulation of gene expression.

Full Name
  • McKeon F.D., et al.,(1986), Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins. Nature 319:463-468.
  • Fisher D.Z., et al., (1986), cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins.Proc. Natl. Acad. Sci. U.S.A. 83:6450-6454.
  • Sylvius N., et al.,(2005), In vivo and in vitro examination of the functional significances of novel lamin gene mutations in heart failure patients.J. Med. Genet. 42:639-647.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Renin Antibody Rabbit Monoclonal ELISA,IHC-P 50279-R001
    Anti-Renin Antibody Rabbit Polyclonal ELISA,IHC-P 50279-RP02
    Anti-Renin Antibody Rabbit Polyclonal ELISA 50279-RP01
    Anti-Renin Antibody Mouse Monoclonal IHC-P 10969-MM04
    Anti-Renin Antibody Rabbit Monoclonal WB,ELISA,IHC-P,ICC/IF,IF 10969-R009
    Anti-Renin Antibody Rabbit Polyclonal ELISA 10969-RP01
    Anti-Renin Antibody Rabbit Polyclonal ELISA 10969-RP02
    Anti-Renin Antibody Rabbit Polyclonal ELISA,IHC-P 10969-T24
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