Renin 1

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

Renin 1 Related Areas

Cardiovascular>>Blood Pressure Regulation>>Renin 1/REN1/REN

Enzyme>>Protease & Regulator>>Aspartate Protease & Regulator>>Renin 1/REN1/REN

Renin 1 Alternative Names

D19352, Ren, Ren-1, Ren-A, Ren1c, Ren1d, Rn-1, Rnr

Summaries for Renin 1

Entrez Gene summary for REN:

Renin 1 catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin 1, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]

Mouse Renin 1 Protein General Information

 

• Protein names: Renin-1
• Sequence length: 402 AA.
• Catalytic activity: Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.
• Enzyme regulation: Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing
• Sequence similarities: Renin 1 belongs to the peptidase A1 family.
• Induction: Renal renin is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sodium concentration.
• Subunit structure: Renin 1 interacts with ATP6AP2
• Subcellular location: Secreted. Membrane. Note: Associated to membranes via binding to ATP6AP2
• Tissue specificity: Kidney.
• Polymorphism: In inbred mouse strains, there are at least two alleles which can occur at the Ren1 locus: Ren-1D and Ren-1C. The sequence shown is that of Ren-1C. Present as a single-copy gene in strains such as BALB/c and C57BL/6 while some strains such as Swiss and Akr contain two copies.

General information above from UniProt

Function for Renin 1 Protein

UniProtKB:

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.