Anti-Renin Antibody

Cat: 50279-RP02
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Anti-Renin Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Renin Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Mouse
Specificity
Mouse Renin
Immunogen
Recombinant Mouse REN1 protein (Catalog#50279-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse REN1 (rM REN1; Catalog#50279-M08H; NP_112469.1; Met 1-Arg 402). REN1 specific IgG was purified by mouse REN1 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Renin Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:2500-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Renin Antibody (Rabbit Polyclonal antibody) Images
Mouse Renin Immunohistochemistry(IHC) 3208
Immunochemical staining of mouse REN1 in mouse kidney with rabbit polyclonal antibody (1:5000, formalin-fixed paraffin embedded sections). Positive staining was localized to juxtaglomerular cell. The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
Anti-Renin Antibody Alternative Names
Anti-D19352 Antibody;Anti-Ren Antibody;Anti-Ren-1 Antibody;Anti-Ren-A Antibody;Anti-Ren1 Antibody;Anti-Ren1c Antibody;Anti-Ren1d Antibody;Anti-Rn-1 Antibody;Anti-Rnr Antibody
Renin Background Information

Renin-1, also known as Ren-1, Angiotensinogenase and Kidney renin, is a member of the peptidase A1 family. Renin-1 is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sodium concentration. androgen and thyroid hormones influence levels of Renin-1 in mouse submandibular gland (SMG) primarily by regulating the amount of Renin-1 mRNA available for translation. Renin-1 is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. It is expressed at relatively low levels in mouse SMG and kidney. Ren-2 is expressed at high levels in the mouse SMG and at very low levels, if at all, in the kidney. Ren-1 and Ren-2 are closely linked on mouse chromosome 1, show extensive homology in coding and noncoding regions and provide a model for studying the regulation of gene expression.

Full Name
renin
References
  • McKeon F.D., et al.,(1986), Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins. Nature 319:463-468.
  • Fisher D.Z., et al., (1986), cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins.Proc. Natl. Acad. Sci. U.S.A. 83:6450-6454.
  • Sylvius N., et al.,(2005), In vivo and in vitro examination of the functional significances of novel lamin gene mutations in heart failure patients.J. Med. Genet. 42:639-647.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Renin Antibody Rabbit Monoclonal ELISA,IHC-P 50279-R001
    Anti-Renin Antibody Rabbit Polyclonal ELISA 50279-RP01
    Anti-Renin Antibody Mouse Monoclonal ELISA,IHC-P 10969-MM01
    Anti-Renin Antibody Mouse Monoclonal IHC-P 10969-MM04
    Anti-Renin Antibody Rabbit Polyclonal ELISA 10969-RP02
    Anti-Renin Antibody Rabbit Polyclonal ELISA,IHC-P 10969-T24
    Anti-Renin Antibody Rabbit Monoclonal WB,ELISA,IHC-P,ICC/IF,IF 10969-R009
    Anti-Renin Antibody Rabbit Polyclonal ELISA 10969-RP01
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