OX40L cDNA ORF Clone, Rat, C-Myc tag

Cat: RG80146-CM
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OX40L cDNA ORF Clone, Rat, C-Myc tag General Information
Gene
Species
Rat
NCBI Ref Seq
RefSeq ORF Size
600 bp
Description
Full length Clone DNA of Rat tumor necrosis factor (ligand) superfamily, member 4 with C terminal Myc tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-C-Myc
Tag Sequence
Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG
Sequencing Primers
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

OX40L Background Information

OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-40L is a ligand for receptor TNFRSF4/OX4. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.

Immune Checkpoint
Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
tumor necrosis factor (ligand) superfamily, member 4
References
  • Lei W. et al., 2012, Ann Acad Med Singapore. 41 (5): 200-4.
  • Lee YH. et al., 2012, Hum Immunol. 73 (10): 1050-4.
  • Weiguang Y. et al., 2012, PLoS One. 7 (8): e41277.
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    OX40L cDNA ORF Clone, Rat, Related Products

    Product Name Catalog#(PDF)
    OX40L cDNA ORF Clone in Cloning Vector, Rat RG80146-G
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    OX40L Lentiviral cDNA ORF Clone, Rat, C-GFPSpark® tag RG80146-ACGLN
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    OX40L cDNA ORF Clone, Rat, C-DDK (Flag®) tag RG80146-CF
    OX40L cDNA ORF Clone, Rat, N-DDK (Flag®) tag RG80146-NF
    OX40L cDNA ORF Clone, Rat, C-His tag RG80146-CH
    OX40L cDNA ORF Clone, Rat, N-His tag RG80146-NH
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    OX40L cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
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    OX40L cDNA ORF Clone, Human, Related Products

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