SLAM / CD150 cDNA ORF Clone, Rat, C-His tag

Cat: RG80349-CH
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SLAM / CD150 cDNA ORF Clone, Rat, C-His tag General Information
Gene
Species
Rat
NCBI Ref Seq
RefSeq ORF Size
1038 bp
Description
Full length Clone DNA of Rat signaling lymphocytic activation molecule family member 1 with C terminal His tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-C-His
Tag Sequence
His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
Sequencing Primers
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

SLAM / CD150 Background Information

CD150/signaling lymphocytic activation molecule (SLAM) is a cell surface sialylated phosphoglycoprotein and belongs to the CD2 subset of the Ig superfamily of type I transmembrane glycoproteins. The CD150 receptor is expressed on thymocytes, activated and memory T cells, B cells, platelets, natural killer T cells, and mature dendritic cells, and is also detected on tumor cells of Hodgkin's lymphoma (HL) and diffuse large B-cell lymphoma with an activated B cell phenotype. Additionally, it is the immune cell receptor for measles virus (MV). As a self-ligand, CD150 performs diverse immunologic functions including T/B-cell costimulation, induction of IFN-&gamma in Th1 T-cell clones, redirection of Th2 clones to a Th1 or Th0 phenotype, and inhibition of apoptosis in B cells. Furthermore, CD150 was shown to be the second receptor for measles virus in addition to CD46, and the distribution of SLAM on various cell lines is consistent with their susceptibility to clinical isolates of measles virus.

Full Name
signaling lymphocytic activation molecule family member 1
References
  • Tatsuo H, et al. (2002) The morbillivirus receptor SLAM (CD150). Microbiol Immunol. 46(3): 135-42.
  • Sidorenko SP, et al. (2003)The dual-function CD150 receptor subfamily: the viral attraction. Nat Immunol. 4(1): 19-24.
  • Yurchenko MY, et al. (2010) CD150 regulates JNK1/2 activation in normal and Hodgkin's lymphoma B cells. Immunol Cell Biol. 88(5): 565-74.
  • Leonard VH, et al. (2010) Measles virus selectively blind to signaling lymphocytic activation molecule (SLAM ; CD150) is attenuated and induces strong adaptive immune responses in rhesus monkeys. J Virol. 84(7): 3413-20.
  • SLAM / CD150 cDNA ORF Clone, Rat, Related Products

    Product Name Catalog#(PDF)
    SLAM / CD150 cDNA ORF Clone in Cloning Vector, Rat RG80349-G
    SLAM / CD150 cDNA ORF Clone, Rat, untagged RG80349-UT
    SLAM / CD150 Lentiviral cDNA ORF Clone, Rat, C-GFPSpark® tag RG80349-ACGLN
    SLAM / CD150 cDNA ORF Clone, Rat, C-GFPSpark® tag RG80349-ACG
    SLAM / CD150 cDNA ORF Clone, Rat, C-OFPSpark® tag RG80349-ACR
    SLAM / CD150 cDNA ORF Clone, Rat, C-DDK (Flag®) tag RG80349-CF
    SLAM / CD150 cDNA ORF Clone, Rat, N-DDK (Flag®) tag RG80349-NF
    SLAM / CD150 cDNA ORF Clone, Rat, N-His tag RG80349-NH
    SLAM / CD150 cDNA ORF Clone, Rat, C-HA tag RG80349-CY
    SLAM / CD150 cDNA ORF Clone, Rat, N-HA tag RG80349-NY
    SLAM / CD150 cDNA ORF Clone, Rat, C-Myc tag RG80349-CM
    SLAM / CD150 cDNA ORF Clone, Rat, N-Myc tag RG80349-NM
    SLAM / CD150 qPCR Primer Pairs, Rat RP300319

    SLAM / CD150 cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    SLAM / CD150 cDNA ORF Clone in Cloning Vector, Human HG10837-M
    SLAM / CD150 cDNA ORF Clone, Human, untagged HG10837-UT
    SLAM / CD150 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10837-ACGLN
    SLAM / CD150 cDNA ORF Clone, Human, C-GFPSpark® tag HG10837-ACG
    SLAM / CD150 cDNA ORF Clone, Human, C-OFPSpark® tag HG10837-ACR
    SLAM / CD150 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10837-CF
    SLAM / CD150 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10837-NF
    SLAM / CD150 cDNA ORF Clone, Human, C-His tag HG10837-CH
    SLAM / CD150 cDNA ORF Clone, Human, N-His tag HG10837-NH
    SLAM / CD150 cDNA ORF Clone, Human, C-HA tag HG10837-CY
    SLAM / CD150 cDNA ORF Clone, Human, N-HA tag HG10837-NY
    SLAM / CD150 cDNA ORF Clone, Human, C-Myc tag HG10837-CM
    SLAM / CD150 cDNA ORF Clone, Human, N-Myc tag HG10837-NM
    SLAM / CD150 qPCR Primer Pairs, Human HP100736
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