|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat PARK7 ORF mammalian expression plasmid, C-GFPSpark tag||RG80500-ACG|
|Rat PARK7 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80500-ACR|
|Rat PARK7 ORF mammalian expression plasmid, N-GFPSpark tag||RG80500-ANG|
|Rat PARK7 ORF mammalian expression plasmid, N-OFPSpark / RFP tag||RG80500-ANR|
|Rat PARK7 ORF mammalian expression plasmid, C-Flag tag||RG80500-CF|
|Rat PARK7 ORF mammalian expression plasmid, C-His tag||RG80500-CH|
|Rat PARK7 ORF mammalian expression plasmid, C-Myc tag||RG80500-CM|
|Rat PARK7 ORF mammalian expression plasmid, C-HA tag||RG80500-CY|
|Rat PARK7 ORF mammalian expression plasmid, N-Flag tag||RG80500-NF|
|Rat PARK7 ORF mammalian expression plasmid, N-His tag||RG80500-NH|
|Rat PARK7 ORF mammalian expression plasmid, N-Myc tag||RG80500-NM|
|Rat PARK7 ORF mammalian expression plasmid, N-HA tag||RG80500-NY|
|Rat PARK7 Gene cDNA clone plasmid||RG80500-U|
|Rat PARK7 natural ORF mammalian expression plasmid||RG80500-UT|
|Learn more about expression Vectors|
Parkinson's disease locus DJ-1 (PARK7) is a differentially expressed transcript. DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress. PARK7 belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Mutations in the DJ-1 gene are associated with rare forms of autosomal recessive early-onset Parkinson's disease (PD). DJ-1/p53 interactions contribute to apoptosis resistance in clonal myeloid cells and may serve as a prognostic marker in patients with myelodysplastic syndromes (MDS). DJ-1 regulates redox signaling kinase pathways and acts as a transcriptional regulator of antioxidative gene batteries. Therefore, DJ-1 is an important redox-reactive signaling intermediate controlling oxidative stress after ischemia, upon neuroinflammation, and during age-related neurodegenerative processes. Augmenting DJ-1 activity might provide novel approaches to treating chronic neurodegenerative illnesses such as Parkinson's disease and acute damage such as stroke.