**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
IL17, also known as IL17a, is a cytokine belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
IL17 cDNA ORF Clone, Marmoset, Related Products
IL17 cDNA ORF Clone, Canine, Related Products
| Product Name | Catalog#(PDF) |
|---|---|
| IL17 cDNA ORF Clone in Cloning Vector, Canine | DG70102-G |
IL17 cDNA ORF Clone, Rhesus, Related Products
IL17 cDNA ORF Clone, Cynomolgus, Related Products
| Product Name | Catalog#(PDF) |
|---|---|
| IL17 Lentiviral cDNA ORF Clone, Cynomolgus, C-GFPSpark® tag | CG90880-ACGLN |
| IL17 cDNA ORF Clone, Cynomolgus, C-His tag | CG90880-CH |
IL17 cDNA ORF Clone, Rabbit, Related Products
IL17 cDNA ORF Clone, Rat, Related Products
IL17 cDNA ORF Clone, Mouse, Related Products
IL17 cDNA ORF Clone, Human, Related Products
