IFNAR1 cDNA ORF Clone, Rat, C-DDK (Flag®) tag

Cat: RG80180-CF
Contact us:
+86-400-890-9989
order@sinobiological.com
Distributors
All IFNAR1 Reagents
CRO Services
Product recommended

All IFNAR1 Reagents
IFNAR1 cDNA ORF Clone, Rat, C-DDK (Flag®) tag General Information
Gene
Species
Rat
NCBI Ref Seq
RefSeq ORF Size
1320 bp
Description
Full length Clone DNA of Rat interferon (alpha, beta and omega) receptor 1 with C terminal Flag tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-C-FLAG
Tag Sequence
FLAG Tag Sequence: GATTACAAGGATGACGACGATAAG
Sequencing Primers
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

IFNAR1 Background Information

Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.

Full Name
interferon (alpha, beta and omega) receptor 1
References
  • Yan H, et al. (1996) Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. EMBO J. 15(5): 1064-74.
  • Richter MF, et al. (1998) Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. J Biol Chem. 273(38): 24723-9.
  • Abramovich C, et al. (1997) A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor. EMBO J. 16(2): 260-6.
  • IFNAR1 cDNA ORF Clone, Rhesus, Related Products

    Product Name Catalog#(PDF)
    IFNAR1 cDNA ORF Clone in Cloning Vector, Rhesus CG90113-G
    IFNAR1 cDNA ORF Clone, Rhesus, untagged CG90113-UT
    IFNAR1 cDNA ORF Clone, Rhesus, C-GFPSpark® tag CG90113-ACG
    IFNAR1 Lentiviral cDNA ORF Clone, Rhesus, C-GFPSpark® tag CG90113-ACGLN
    IFNAR1 cDNA ORF Clone, Rhesus, C-OFPSpark® tag CG90113-ACR
    IFNAR1 cDNA ORF Clone, Rhesus, C-DDK (Flag®) tag CG90113-CF
    IFNAR1 cDNA ORF Clone, Rhesus, N-DDK (Flag®) tag CG90113-NF
    IFNAR1 cDNA ORF Clone, Rhesus, C-His tag CG90113-CH
    IFNAR1 cDNA ORF Clone, Rhesus, N-His tag CG90113-NH
    IFNAR1 cDNA ORF Clone, Rhesus, C-HA tag CG90113-CY
    IFNAR1 cDNA ORF Clone, Rhesus, N-HA tag CG90113-NY
    IFNAR1 cDNA ORF Clone, Rhesus, C-Myc tag CG90113-CM
    IFNAR1 cDNA ORF Clone, Rhesus, N-Myc tag CG90113-NM

    IFNAR1 cDNA ORF Clone, Rat, Related Products

    Product Name Catalog#(PDF)
    IFNAR1 cDNA ORF Clone in Cloning Vector, Rat RG80180-G
    IFNAR1 cDNA ORF Clone, Rat, untagged RG80180-UT
    IFNAR1 Lentiviral cDNA ORF Clone, Rat, C-GFPSpark® tag RG80180-ACGLN
    IFNAR1 cDNA ORF Clone, Rat, C-GFPSpark® tag RG80180-ACG
    IFNAR1 cDNA ORF Clone, Rat, C-OFPSpark® tag RG80180-ACR
    IFNAR1 cDNA ORF Clone, Rat, N-DDK (Flag®) tag RG80180-NF
    IFNAR1 cDNA ORF Clone, Rat, C-His tag RG80180-CH
    IFNAR1 cDNA ORF Clone, Rat, N-His tag RG80180-NH
    IFNAR1 cDNA ORF Clone, Rat, C-HA tag RG80180-CY
    IFNAR1 cDNA ORF Clone, Rat, N-HA tag RG80180-NY
    IFNAR1 cDNA ORF Clone, Rat, C-Myc tag RG80180-CM
    IFNAR1 cDNA ORF Clone, Rat, N-Myc tag RG80180-NM
    IFNAR1 qPCR Primer Pairs, Rat RP300173

    IFNAR1 cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    IFNAR1 cDNA ORF Clone in Cloning Vector, Mouse MG50469-M
    IFNAR1 cDNA ORF Clone, Mouse, untagged MG50469-UT
    IFNAR1 cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50469-ACG
    IFNAR1 Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50469-ACGLN
    IFNAR1 cDNA ORF Clone, Mouse, C-OFPSpark® tag MG50469-ACR
    IFNAR1 cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50469-CF
    IFNAR1 cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG50469-NF
    IFNAR1 cDNA ORF Clone, Mouse, C-His tag MG50469-CH
    IFNAR1 cDNA ORF Clone, Mouse, N-His tag MG50469-NH
    IFNAR1 cDNA ORF Clone, Mouse, C-HA tag MG50469-CY
    IFNAR1 cDNA ORF Clone, Mouse, N-HA tag MG50469-NY
    IFNAR1 cDNA ORF Clone, Mouse, C-Myc tag MG50469-CM
    IFNAR1 cDNA ORF Clone, Mouse, N-Myc tag MG50469-NM
    IFNAR1 qPCR Primer Pairs, Mouse MP200077

    IFNAR1 cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    IFNAR1 cDNA ORF Clone in Cloning Vector, Human HG13222-U
    IFNAR1 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG13222-ACGLN
    IFNAR1 qPCR Primer Pairs, Human HP100058
    info info
    添加购物车成功! 添加购物车失败!