Rat GSK3B cDNA Clone

Rat GSK3B cDNA Clone Products

Sino Biological is the new leader in life science research tool developer worldwide. All our proteins are manufactured in bulk quantities using sequence verified vectors and state-of-the-art mammalian, insect, or E. coli expression processes. All reagents are available in both small retails and bulk packages - both offering 30-80% cost saving compared to currently leading brands. We installed the same quality requirement and assurance for preclinical products to reagent products, hence the quality of Sino Biological products is typically higher than that of other reagent providers.

Browse GSK3B cDNA Clone Products by following categories

GSK3B Protein , Antibody, ELISA Kit, cDNA Clone

• GSK3B cDNA Clone

  – Human GSK3B cDNA Clone

  – Mouse GSK3B cDNA Clone

  – Rat GSK3B cDNA Clone

  – Rhesus GSK3B cDNA Clone

  – Cynomolgus GSK3B cDNA Clone

  – Canine (Dog) GSK3B cDNA Clone

  – Ferret GSK3B cDNA Clone

  – Bovine GSK3B cDNA Clone

Rat GSK3B cDNA Clone Products

All GSK3B Products list

• GSK3B cDNA Clone

  – Rat GSK3B cDNA Clone

Additional GSK3B Products

• GSK3B Protein

• GSK3B Antibody

• GSK3B ELISA Kit

Summary of Rat GSK3B cDNA Clone

Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules.

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