Endoglin / CD105 cDNA ORF Clone, Rat, C-Myc tag

Cat: RG80140-CM
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Endoglin / CD105 cDNA ORF Clone, Rat, C-Myc tag General Information
Gene
Species
Rat
NCBI Ref Seq
RefSeq ORF Size
1953 bp
Description
Full length Clone DNA of Rat endoglin with C terminal Myc tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-C-Myc
Tag Sequence
Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG
Sequencing Primers
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

Endoglin / CD105 Background Information

Endoglin, also known as CD105, is a type I  homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type I I receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types.

Full Name
endoglin
References
  • Bellon T., et al.,(1993), Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions. Eur. J. Immunol. 23:2340-2345.
  • Humphray S.J., et al., (2004), DNA sequence and analysis of human chromosome 9.Nature 429:369-374.
  • Gougos A., et al.,(1990), Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells.J. Biol. Chem. 265:8361-8364.
  • Endoglin / CD105 cDNA ORF Clone, Rat, Related Products

    Product Name Catalog#(PDF)
    Endoglin / CD105 cDNA ORF Clone in Cloning Vector, Rat RG80140-G
    Endoglin / CD105 cDNA ORF Clone, Rat, untagged RG80140-UT
    Endoglin / CD105 cDNA ORF Clone, Rat, C-GFPSpark® tag RG80140-ACG
    Endoglin / CD105 Lentiviral cDNA ORF Clone, Rat, C-GFPSpark® tag RG80140-ACGLN
    Endoglin / CD105 cDNA ORF Clone, Rat, C-OFPSpark® tag RG80140-ACR
    Endoglin / CD105 cDNA ORF Clone, Rat, C-DDK (Flag®) tag RG80140-CF
    Endoglin / CD105 cDNA ORF Clone, Rat, N-DDK (Flag®) tag RG80140-NF
    Endoglin / CD105 cDNA ORF Clone, Rat, C-His tag RG80140-CH
    Endoglin / CD105 cDNA ORF Clone, Rat, N-His tag RG80140-NH
    Endoglin / CD105 cDNA ORF Clone, Rat, C-HA tag RG80140-CY
    Endoglin / CD105 cDNA ORF Clone, Rat, N-HA tag RG80140-NY
    Endoglin / CD105 cDNA ORF Clone, Rat, N-Myc tag RG80140-NM
    Endoglin / CD105 qPCR Primer Pairs, Rat RP300136

    Endoglin / CD105 cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    Endoglin / CD105 cDNA ORF Clone in Cloning Vector, Mouse MG50407-M
    Endoglin / CD105 cDNA ORF Clone, Mouse, untagged MG50407-UT
    Endoglin / CD105 cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50407-ACG
    Endoglin / CD105 Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50407-ACGLN
    Endoglin / CD105 cDNA ORF Clone, Mouse, C-OFPSpark® tag MG50407-ACR
    Endoglin / CD105 cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50407-CF
    Endoglin / CD105 cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG50407-NF
    Endoglin / CD105 cDNA ORF Clone, Mouse, C-His tag MG50407-CH
    Endoglin / CD105 cDNA ORF Clone, Mouse, N-His tag MG50407-NH
    Endoglin / CD105 cDNA ORF Clone, Mouse, C-HA tag MG50407-CY
    Endoglin / CD105 cDNA ORF Clone, Mouse, N-HA tag MG50407-NY
    Endoglin / CD105 cDNA ORF Clone, Mouse, C-Myc tag MG50407-CM
    Endoglin / CD105 cDNA ORF Clone, Mouse, N-Myc tag MG50407-NM
    Endoglin / CD105 qPCR Primer Pairs, Mouse MP200084

    Endoglin / CD105 cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    Endoglin / CD105 cDNA ORF Clone in Cloning Vector, Human HG10149-M
    Endoglin / CD105 cDNA ORF Clone, Human, untagged HG10149-UT
    Endoglin / CD105 cDNA ORF Clone, Human, C-GFPSpark® tag HG10149-ACG
    Endoglin / CD105 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10149-ACGLN
    Endoglin / CD105 cDNA ORF Clone, Human, C-OFPSpark® tag HG10149-ACR
    Endoglin / CD105 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10149-CF
    Endoglin / CD105 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10149-NF
    Endoglin / CD105 cDNA ORF Clone, Human, C-His tag HG10149-CH
    Endoglin / CD105 cDNA ORF Clone, Human, N-His tag HG10149-NH
    Endoglin / CD105 cDNA ORF Clone, Human, C-HA tag HG10149-CY
    Endoglin / CD105 cDNA ORF Clone, Human, N-HA tag HG10149-NY
    Endoglin / CD105 cDNA ORF Clone, Human, C-Myc tag HG10149-CM
    Endoglin / CD105 cDNA ORF Clone, Human, N-Myc tag HG10149-NM
    Endoglin / CD105 qPCR Primer Pairs, Human HP100220
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