CCR4/CD194 cDNA ORF Clone, Rat, N-DDK (Flag®) tag

Cat: RG80357-NF
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CCR4/CD194 cDNA ORF Clone, Rat, N-DDK (Flag®) tag General Information
Gene
Species
Rat
NCBI Ref Seq
RefSeq ORF Size
1083 bp
Description
Full length Clone DNA of Rat chemokine (C-C motif) receptor 4 with N terminal Flag tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-SP-N-FLAG
Tag Sequence
FLAG Tag Sequence: GATTACAAGGATGACGACGATAAG
Sequencing Primers
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

CCR4/CD194 Background Information

CCR4 is a chemokine receptor that has a critical role in immune cell trafficking. T-helper type 2 cells (Th2), regulatory T cells (Treg), interluekin-17–producing T-helper cells (Th17), and skin-homing memory T cells express CCR4 on their surface and migrate toward the chemokines CCL17 and CCL22.
CCR4, a C-C type chemokine receptor, has previously been focused on its biological function in immunopathogenesis of hematological tumors. To date, relatively little attention has been paid to the role of CCR4 in promoting metastasis of some solid tumors, including gastric cancer. Our group has shown that the lymphocyte-rich gastric cancers tend to be more frequently positive for CCR4, and found a novel role of CCR4 in tumor-induced immunosuppression, indicating various expression profiles of CCR4 in gastric cancer tissues and multifunctional roles of this molecule in gastric cancer progression.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
chemokine (C-C motif) receptor 4
References
  • Yang Y, Du L, Yang X, et al. Aberrant CCR4 Expression Is Involved in Tumor Invasion of Lymph Node-Negative Human Gastric Cancer. Tang C-H, ed. PLoS ONE. 2015;10(3):e0120059. doi:10.1371/journal.pone.0120059.
  • Nakagawa M, Schmitz R, Xiao W, et al. Gain-of-function CCR4 mutations in adult T cell leukemia/lymphoma. The Journal of Experimental Medicine. 2014;211(13):2497-2505.
  • CCR4/CD194 cDNA ORF Clone, Rhesus, Related Products

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    CCR4/CD194 cDNA ORF Clone in Cloning Vector, Rhesus CG90237-G
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    CCR4/CD194 cDNA ORF Clone, Rhesus, N-His tag CG90237-NH
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    CCR4/CD194 cDNA ORF Clone, Rat, Related Products

    Product Name Catalog#(PDF)
    CCR4/CD194 cDNA ORF Clone in Cloning Vector, Rat RG80357-G
    CCR4/CD194 cDNA ORF Clone, Rat, untagged RG80357-UT
    CCR4/CD194 Lentiviral cDNA ORF Clone, Rat, C-GFPSpark® tag RG80357-ACGLN
    CCR4/CD194 cDNA ORF Clone, Rat, C-GFPSpark® tag RG80357-ACG
    CCR4/CD194 cDNA ORF Clone, Rat, C-OFPSpark® tag RG80357-ACR
    CCR4/CD194 cDNA ORF Clone, Rat, C-DDK (Flag®) tag RG80357-CF
    CCR4/CD194 cDNA ORF Clone, Rat, C-His tag RG80357-CH
    CCR4/CD194 cDNA ORF Clone, Rat, N-His tag RG80357-NH
    CCR4/CD194 cDNA ORF Clone, Rat, C-HA tag RG80357-CY
    CCR4/CD194 cDNA ORF Clone, Rat, N-HA tag RG80357-NY
    CCR4/CD194 cDNA ORF Clone, Rat, C-Myc tag RG80357-CM
    CCR4/CD194 cDNA ORF Clone, Rat, N-Myc tag RG80357-NM
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    CCR4/CD194 cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
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