ACE2 cDNA ORF Clone, Rat, C-DDK (Flag®) tag

Cat: RG80031-CF
Contact us:
215-583-7898
order@sinobiological.com
Distributors
All ACE2 Reagents
CRO Services
Product recommended

All ACE2 Reagents
ACE2 cDNA ORF Clone, Rat, C-DDK (Flag®) tag General Information
Gene
Species
Rat
NCBI Ref Seq
RefSeq ORF Size
2418 bp
Description
Full length Clone DNA of Rat angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 with C terminal Flag tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-C-FLAG
Tag Sequence
FLAG Tag Sequence: GATTACAAGGATGACGACGATAAG
Sequencing Primers
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

ACE2 Background Information

Angiotensin-converting enzyme 2 (ACE2), a first homolog of ACE, regulates the renin angiotensin system (RAS) by counterbalancing ACE activity. Accumulating evidence in recent years has demonstrated a physiological and pathological role of ACE2 in the cardiovascular, renal and respiratory systems. ACE2 also has an important role in blood pressure control. This enzyme, an homolog of ACE, hydrolyzes angiotensin (Ang) I to produce Ang-(1-9), which is subsequently converted into Ang-(1-7) by a neutral endopeptidase and ACE. ACE2 releases Ang-(1-7) more efficiently than its catalysis of Ang-(1-9) by cleavage of Pro(7)-Phe(8) bound in Ang II. Thus, the major biologically active product of ACE2 is Ang-(1-7), which is considered to be a beneficial peptide of the RAS cascade in the cardiovascular system. A physiological role for ACE2 has been implicated in hypertension, cardiac function, heart function and diabetes, and as a receptor of the severe acute respiratory syndrome coronavirus. In the acute respiratory distress syndrome (ARDS), ACE, AngII, and AT1R promote the disease pathogenesis, whereas ACE2 and the AT2R protect from ARDS. Importantly, ACE2 has been identified as a key SARS-coronavirus receptor and plays a protective role in severe acute respiratory syndrome (SARS) pathogenesis. Furthermore, the recent explosion of research into the ACE2 homolog, collectrin, has revealed a new physiological function of ACE2 as an amino acid transporter, which explains the pathogenic role of gene mutations in Hartnup disorder. This review summarizes and discusses the recently unveiled roles for ACE2 in disease pathogenesis.

Full Name
angiotensin I converting enzyme 2
References
  • Koitka A, et al. (2008) Angiotensin converting enzyme 2 in the kidney. Clin Exp Pharmacol Physiol. 35(4): 420-5.
  • Raizada MK, et al. (2007) ACE2: a new target for cardiovascular disease therapeutics. J Cardiovasc Pharmacol. 50(2): 112-9.
  • Imai Y, et al. (2007) Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis. Circ J. 74(3): 405-10.
  • Turner AJ, et al. (2004) ACE2: from vasopeptidase to SARS virus receptor. Trends Pharmacol Sci. 25(6): 291-4.
  • ACE2 cDNA ORF Clone, Rhesus, Related Products

    Product Name Catalog#(PDF)
    ACE2 cDNA ORF Clone in Cloning Vector, Rhesus CG90211-G
    ACE2 cDNA ORF Clone, Rhesus, untagged CG90211-UT
    ACE2 cDNA ORF Clone, Rhesus, C-GFPSpark® tag CG90211-ACG
    ACE2 Lentiviral cDNA ORF Clone, Rhesus, C-GFPSpark® tag CG90211-ACGLN
    ACE2 cDNA ORF Clone, Rhesus, C-OFPSpark® tag CG90211-ACR
    ACE2 cDNA ORF Clone, Rhesus, C-DDK (Flag®) tag CG90211-CF
    ACE2 cDNA ORF Clone, Rhesus, N-DDK (Flag®) tag CG90211-NF
    ACE2 cDNA ORF Clone, Rhesus, C-His tag CG90211-CH
    ACE2 cDNA ORF Clone, Rhesus, N-His tag CG90211-NH
    ACE2 cDNA ORF Clone, Rhesus, C-HA tag CG90211-CY
    ACE2 cDNA ORF Clone, Rhesus, N-HA tag CG90211-NY
    ACE2 cDNA ORF Clone, Rhesus, C-Myc tag CG90211-CM
    ACE2 cDNA ORF Clone, Rhesus, N-Myc tag CG90211-NM

    ACE2 cDNA ORF Clone, Rat, Related Products

    Product Name Catalog#(PDF)
    ACE2 cDNA ORF Clone in Cloning Vector, Rat RG80031-M
    ACE2 cDNA ORF Clone, Rat, untagged RG80031-UT
    ACE2 cDNA ORF Clone, Rat, C-GFPSpark® tag RG80031-ACG
    ACE2 Lentiviral cDNA ORF Clone, Rat, C-GFPSpark® tag RG80031-ACGLN
    ACE2 cDNA ORF Clone, Rat, C-OFPSpark® tag RG80031-ACR
    ACE2 cDNA ORF Clone, Rat, N-DDK (Flag®) tag RG80031-NF
    ACE2 cDNA ORF Clone, Rat, C-His tag RG80031-CH
    ACE2 cDNA ORF Clone, Rat, N-His tag RG80031-NH
    ACE2 cDNA ORF Clone, Rat, C-HA tag RG80031-CY
    ACE2 cDNA ORF Clone, Rat, N-HA tag RG80031-NY
    ACE2 cDNA ORF Clone, Rat, C-Myc tag RG80031-CM
    ACE2 cDNA ORF Clone, Rat, N-Myc tag RG80031-NM
    ACE2 qPCR Primer Pairs, Rat RP300030

    ACE2 cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    ACE2 cDNA ORF Clone in Cloning Vector, Mouse MG50249-M
    ACE2 cDNA ORF Clone, Mouse, untagged MG50249-UT
    ACE2 Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50249-ACGLN
    ACE2 cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50249-ACG
    ACE2 cDNA ORF Clone, Mouse, C-OFPSpark® tag MG50249-ACR
    ACE2 cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50249-CF
    ACE2 cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG50249-NF
    ACE2 cDNA ORF Clone, Mouse, C-His tag MG50249-CH
    ACE2 cDNA ORF Clone, Mouse, N-His tag MG50249-NH
    ACE2 cDNA ORF Clone, Mouse, C-HA tag MG50249-CY
    ACE2 cDNA ORF Clone, Mouse, N-HA tag MG50249-NY
    ACE2 cDNA ORF Clone, Mouse, C-Myc tag MG50249-CM
    ACE2 cDNA ORF Clone, Mouse, N-Myc tag MG50249-NM
    ACE2 qPCR Primer Pairs, Mouse MP200275

    ACE2 cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    ACE2 cDNA ORF Clone in Cloning Vector, Human HG10108-M
    ACE2 cDNA ORF Clone, Human, untagged HG10108-UT
    ACE2 cDNA ORF Clone, Human, C-GFPSpark® tag HG10108-ACG
    ACE2 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10108-ACGLN
    ACE2 cDNA ORF Clone, Human, C-OFPSpark® tag HG10108-ACR
    ACE2 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10108-CF
    ACE2 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10108-NF
    ACE2 cDNA ORF Clone, Human, C-His tag HG10108-CH
    ACE2 cDNA ORF Clone, Human, N-His tag HG10108-NH
    ACE2 cDNA ORF Clone, Human, C-HA tag HG10108-CY
    ACE2 cDNA ORF Clone, Human, N-HA tag HG10108-NY
    ACE2 cDNA ORF Clone, Human, C-Myc tag HG10108-CM
    ACE2 cDNA ORF Clone, Human, N-Myc tag HG10108-NM
    ACE2 qPCR Primer Pairs, Human HP100185
    info info
    添加购物车成功! 添加购物车失败!