All RAF1 reagents are produced in house and quality controlled, including 1 RAF1 Antibody, 26 RAF1 Gene, 1 RAF1 Lysate, 1 RAF1 Protein, 2 RAF1 qPCR. All RAF1 reagents are ready to use.
Recombinant RAF1 proteins are expressed by Baculovirus-Insect Cells with fusion tags as N-His & GST.
RAF1antibodies are validated with different applications, which are WB.
RAF1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each RAF1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Expression host: Baculovirus-Insect Cells
RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.