RAF1 (Protein | Antibody | cDNA Clone | ELISA Kit)

All RAF1 reagents are produced in house and quality controlled, including 2 RAF1 Antibody, 28 RAF1 Gene, 1 RAF1 Lysate, 1 RAF1 Protein, 2 RAF1 qPCR. All RAF1 reagents are ready to use.

RAF1 Background

RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

RAF1 References

  • Zhang K, Chen H, Zhang B, et al. Overexpression of Raf-1 and ERK1/2 in sacral chordoma and association with tumor recurrence. International Journal of Clinical and Experimental Pathology. 2015;8(1):608-614.