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|Catalog||Size (Price)||Quantity||In Stock||Operation|
Reticulon 4 receptor Protein Datasheet
RTN4R / NOGOR Protein Price Inquiry ( Available Sizes )
RTN4R / NOGOR Protein Product Information
|Synonym :||RTN4R, NOGOR|
A DNA sequence encoding the human RTN4R (Q9BZR6) (Met1-Ser447) was expressed with a polyhistidine tag at the C-terminus.
|Expression Host:||Human Cells|
RTN4R / NOGOR Protein QC Testing
|Purity:||> 90% as determined by SDS-PAGE||SDS-PAGE:
RTN4R / NOGOR protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Cys 27|
|Molecular Mass:||The recombinant human RTN4R consists of 433 amino acids and predicts a molecular mass of 46.8 KDa. It migrates as an approximately 60 KDa band in SDS-PAGE under reducing conditions.|
|Formulation:||Lyophilized from sterile PBS, pH 7.4.
RTN4R / NOGOR Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
RTN4R / NOGOR Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|Nogo R/RTN4R||Human||NOGO R/RTN4R/Fc Protein, Recombinant||10466-H03H|
|Nogo R/RTN4R||Human||RTN4R / NOGOR Protein, Recombinant||10466-H08H|
|Nogo R/RTN4R||Mouse||NOGO R/RTN4R Protein, Recombinant||50106-M03H|
|Nogo R/RTN4R||Mouse||NOGO R/RTN4R Protein, Recombiant||50106-M08H|
RTN4R / NOGOR Protein Description
Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 10 LRP (Leucine-rich) repeats. RTN4R is expressed predominantly in neurons and their axons in the central nervous systems (CNS). As a receptor for myelin-derived proteins Nogo, myelin-associated glycoprotein (MAG), and myelin oligodendrocyte glycoprotein (OMG), RTN4R mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult CNS. It has been shown that RTN4R performs its inhibitory actions by interacting with the p75 neurotrophin receptor (p75NTR), a TNFRSF member also known for modulating the activities of the Trk family and for inducing apoptosis in neurons and oligodendrocytes. RTN4R may be proposed as a potential drug target for treatment of various neurological conditions such as spinal cord injury, CNS lesions, peripheral nerve injury, stroke and Alzheimer's disease (AD). Additionally, RTN4R may play a role in regulating the function of the gap junctions.
- Wang X. et al., 2006, Ann Neurol. 60 (5): 540-9.
- Wang YZ. et al., 2006, Neuroreport. 17 (6): 605-9.
- Zhu HY. et al., 2007, Hum Pathol. 38 (3): 426-34.?
- David S. et al., 2008, Trends Neurosci. 31 (5): 221-6.
- Jiang W. et al., 2009, Transl Res. 154 (1): 40-8.
- Zhang L. et al., 2009, J Neurosci, 9 (19): 6348-52.