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Human Nogo Receptor / NOGOR / RTN4R Protein (His Tag)

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Human RTN4R Protein Product Information
Protein Construction:A DNA sequence encoding the human RTN4R (Q9BZR6) (Met1-Ser447) was expressed with a polyhistidine tag at the C-terminus.
Expressed Host:Human Cells
Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Human RTN4R Protein QC Testing
Purity:> 85 % as determined by SDS-PAGE
Endotoxin:< 1.0 EU per μg of the protein as determined by the LAL method
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:Cys 27
Molecule Mass:The recombinant human RTN4R consists of 433 amino acids and predicts a molecular mass of 46.8 KDa. It migrates as an approximately 60 KDa band in SDS-PAGE under reducing conditions.
Formulation:Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Human RTN4R Protein Usage Guide
Storage:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Human RTN4R Protein SDS-PAGE
Human Nogo Receptor / NOGOR / RTN4R Protein (His Tag) SDS-PAGE

RTN4R Related Pathways

    Other RTN4R Recombinant Protein Products
    Nogo Receptor Background

    Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 10 LRP (Leucine-rich) repeats. RTN4R is expressed predominantly in neurons and their axons in the central nervous systems (CNS). As a receptor for myelin-derived proteins Nogo, myelin-associated glycoprotein (MAG), and myelin oligodendrocyte glycoprotein (OMG), RTN4R mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult CNS. It has been shown that RTN4R performs its inhibitory actions by interacting with the p75 neurotrophin receptor (p75NTR), a TNFRSF member also known for modulating the activities of the Trk family and for inducing apoptosis in neurons and oligodendrocytes. RTN4R may be proposed as a potential drug target for treatment of various neurological conditions such as spinal cord injury, CNS lesions, peripheral nerve injury, stroke and Alzheimer's disease (AD). Additionally, RTN4R may play a role in regulating the function of the gap junctions.

    Human Nogo Receptor References

    1. Wang, X. et al., 2006, Ann Neurol. 60(5): 540-549.      

    2. Wang, Y.Z. et al., 2006, Neuroreport.17(6):605-609.       

    3. Zhu, H.Y. et al., 2007, Hum Pathol. 38(3): 426-434.           

    4. David, S. et al., 2008, Trends Neurosci. 31(5): 221-226.       

    5. Jiang, W. et al., 2009, Transl Res. 154(1): 40-48.      

    6. Zhang, L. et al., 2009, J Neurosci, 9(19): 6348-6352.

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        All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.