RTN4 cDNA ORF Clone in Cloning Vector, Human

Cat: HG12261-G

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RTN4 cDNA ORF Clone in Cloning Vector, Human General Information
Gene
Species
Human
NCBI Ref Seq
RefSeq ORF Size
600 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
ORF Clone of Human reticulon 4 DNA.
Plasmid
Vector
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
RTN4 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

RTN4 cDNA ORF Clone in Cloning Vector, Human Alternative Names
ASY cDNA ORF Clone, Human;DGU cDNA ORF Clone, Human;DKFZp781L1143 cDNA ORF Clone, Human;HIGM4 cDNA ORF Clone, Human;Nbla00271 cDNA ORF Clone, Human;Nbla10545 cDNA ORF Clone, Human;NI220/250 cDNA ORF Clone, Human;NOGO cDNA ORF Clone, Human;NOGO-A cDNA ORF Clone, Human;Nogo-B cDNA ORF Clone, Human;Nogo-C cDNA ORF Clone, Human;NOGOC cDNA ORF Clone, Human;NSP cDNA ORF Clone, Human;NSP-CL cDNA ORF Clone, Human;RTN-X cDNA ORF Clone, Human;RTN4-A cDNA ORF Clone, Human;RTN4-B1 cDNA ORF Clone, Human;RTN4-B2 cDNA ORF Clone, Human;RTN4-C cDNA ORF Clone, Human;UDG cDNA ORF Clone, Human;UNG1 cDNA ORF Clone, Human;UNG15 cDNA ORF Clone, Human;UNG2 cDNA ORF Clone, Human
RTN4 Background Information

Reticulon-4, also known as Foocen, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5 and RTN4, is a multi-pass membrane protein which contains one reticulon domain. Isoform 1 of RTN4 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 of RTN4 is widely expressed except for the liver. Isoform 3 of RTN4 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 of RTN4 is testis-specific. Reticulon-4 / RTN4 is a developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Reticulon-4 / RTN4 regulates neurite fasciculation, branching and extension in the developing nervous system. Reticulon-4 / RTN4 is involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. It regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. Isoform 2 of RTN4 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 of RTN4 inhibit BACE1 activity and amyloid precursor protein processing.

Full Name
reticulon 4
References
  • Yang J., et al., 2000, Cytogenet. Cell Genet. 88:101-102.
  • Prinjha R., et al., 2000, Nature 403: 383-384.
  • Tagami S., et al., 2000, Oncogene 19: 5736-5746.
  • Murayama K.S., et al., 2006, Eur. J. Neurosci. 24: 1237-1244.
  • Daub H., et al., 2008, Mol. Cell 31:438-448.
  • Choudhary C., et al., 2009, Science 325: 834-840.
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