RSPO3 Protein

R-Spondin 3

RSPO3 Products

RSPO3 Protein, Recombinant

Molecule	Species	Description	Cat. No
RSPO3	Human	RSPO3 (aa 1-146) Protein, Recombinant	11185-H08H1

RSPO3 cDNA Clone

Molecule	Species	Description	Cat. No
RSPO3	Human	Human RSPO3 full length cDNA Clone / ORF Clone	HG11185-M
RSPO3	Mouse	Mouse RSPO3 cDNA Clone / ORF Clone	MG50606-M

RSPO3 Alternative Names

RSPO3, R-Spondin 3, CRISTIN1, FLJ14440, PWTSR, THSD2 [Homo sapiens]

Rspo3, R-Spondin 3, 2810459H04Rik, AW742308, Cristin1, MGC118442, Thsd2 [Mus musculus]

RSPO3 Background

R-spondin 3 (RSPO3) is a member of the R-Spondin (RSPO) family in vertebrates that activate Wnt/beta-catenin signaling, plays a key role in these processes. The RSPO family of secreted Wnt modulators is involved in development and disease and holds therapeutic promise as stem cell growth factors. The four members have high structural homology. RSPO2 and RSPO3 are more potent than RSPO1, whereas RSPO4 is relatively inactive. All RSPO members require Wnt ligands and LRP6 for activity and amplify signaling of Wnt3A, Wnt1, and Wnt7A, suggesting that RSPO proteins are general regulators of canonical Wnt signaling. RSPO3/PCP signaling during gastrulation requires Wnt5a and is transduced via Fz7, Dvl, and JNK. RSPO3 functions by inducing Sdc4-dependent, clathrin-mediated endocytosis. RSPO3 is a novel, evolutionarily conserved angiogenic factor in embryogenesis. RSPO3 has a key role in the interaction between chorion and allantois in labyrinthine development.

RSPO3 Related Studies

1. Aoki M, et al. (2007) R-spondin3 is required for mouse placental development. Dev Biol. 301(1): 218-26.
2. Kazanskaya O, et al. (2008) The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development. Development. 135(22): 3655-64.
3. Kim KA, et al. (2008) R-Spondin family members regulate the Wnt pathway by a common mechanism. Mol Biol Cell. 19(6): 2588-96.
4. Ohkawara B, et al. (2011) Rspo3 Binds Syndecan 4 and Induces Wnt/PCP Signaling via Clathrin-Mediated Endocytosis to Promote Morphogenesis. Dev Cell. 20(3): 303-14.