Anti-RSPO1 Antibody

Cat: 11083-RP02

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Anti-RSPO1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-RSPO1 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human RSPO1
Recombinant Human RSPO1 protein (Catalog#11083-H08H)
Produced in rabbits immunized with purified, recombinant Human RSPO1 / R-spondin-1 (rh RSPO1; Catalog#11083-H08H; NP_001033722.1; Met 1-Ala 263). RSPO1 specific IgG was purified by human RSPO1 affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-RSPO1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:1000  
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-RSPO1 Antibody (Rabbit Polyclonal antibody) Images
Human R-Spondin 1/RSPO1 Western blot (WB) 13337

Anti-RSPO1 rabbit polyclonal antibody at 1:500 dilution

Lane A: HL-60 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.


Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:29 kDa

Observed band size:24 kDa

Anti-RSPO1 Antibody Alternative Names
Anti-CRISTIN3 Antibody;Anti-R-Spondin 1 Antibody;Anti-RSPO Antibody
RSPO1 Background Information

RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. This protein is an activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO1 acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. It also acts as a ligand for frizzled FZD8 and LRP6.

Full Name
R-spondin 1
  • Kamata T, et al. (2004) R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants. Biochim Biophys Acta. 1676(1):51-62.
  • Ota T, et al. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 36(1):40-5.
  • Strausberg RL, et al. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci. 99(26):16899-903.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-RSPO1 Antibody Rabbit Polyclonal ELISA 50316-T16
    Anti-RSPO1 Antibody Rabbit Polyclonal ELISA,IHC-P 50316-T24
    Anti-RSPO1 Antibody Rabbit Polyclonal ELISA 11083-T16
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