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R-Spondin 1 / RSPO1 Antibody, Rabbit PAb, Antigen Affinity Purified

  • R-Spondin 1 / RSPO1 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
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Human RSPO1 Antibody Product Information
Immunogen:Recombinant Human RSPO1 protein (Catalog#11083-H08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human RSPO1 / R-spondin-1 (rh RSPO1; Catalog#11083-H08H; NP_001033722.1; Met 1-Ala 263). RSPO1 specific IgG was purified by human RSPO1 affinity chromatography.
Human RSPO1 Antibody WB Application Image
Other RSPO1 Antibody Products
R-Spondin 1/RSPO1 Background

RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. This protein is an activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO1 acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. It also acts as a ligand for frizzled FZD8 and LRP6.

Human R-Spondin 1/RSPO1 References
  • Kamata T, et al. (2004) R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants. Biochim Biophys Acta. 1676(1):51-62.
  • Ota T, et al. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 36(1):40-5.
  • Strausberg RL, et al. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci. 99(26):16899-903.
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    Catalog: 11083-RP02-200
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    Datasheet & Documentation

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