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R-Spondin 1/RSPO1 Rabbit PAb

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    Human RSPO1 Antibody Product Information
    Immunogen:Recombinant Human RSPO1 protein (Catalog#11083-H08H)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:Produced in rabbits immunized with purified, recombinant Human RSPO1 / R-spondin-1 (rh RSPO1; Catalog#11083-H08H; NP_001033722.1; Met 1-Ala 263). Total IgG was purified by Protein A affinity chromatography.
    Other RSPO1 Antibody Products
    Reactivity: Human  
    Application: ELISA  WB  
    • Slide 1
    11083-RP02-200
    11083-RP02-50
    11083-RP02-100
    200 µg 
    50 µg 
    100 µg 
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    Reactivity: Mouse  
    Application: ELISA  
      50316-T16-100
      50316-T16-50
      50316-T16-200
      100 µg 
      50 µg 
      200 µg 
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      R-Spondin 1/RSPO1 Background

      RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. This protein is an activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO1 acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. It also acts as a ligand for frizzled FZD8 and LRP6.

      Human R-Spondin 1/RSPO1 References
    • Kamata T, et al. (2004) R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants. Biochim Biophys Acta. 1676(1):51-62.
    • Ota T, et al. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 36(1):40-5.
    • Strausberg RL, et al. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci. 99(26):16899-903.
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