RSK4 (RPS6KA6)

RSK4 is constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participates in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.

RSK4 (RPS6KA6) Related Areas

Enzyme>>Protein Kinase>>Intracellular Kinase>>Ribosomal Protein S6 Kinase (RSK)>>RSK4/RPS6KA6

Signal Transduction>>Protein Kinase>>Intracellular Kinase>>Ribosomal Protein S6 Kinase (RSK)>>RSK4/RPS6KA6

RSK4 (RPS6KA6) Alternative Names

RSK4, RPS6KA6, PP90RSK4 [Homo sapiens]

RSK4, Rps6ka6, RP24-250C1.1, 2610524K04Rik [Mus musculus]

Summaries for RSK4 (RPS6KA6)

Entrez Gene summary for RPS6KA6:

This RPS6KA6 gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. RSK4 may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010]

Human RSK4 (RPS6KA6) Protein General Information

 

• Protein names: Ribosomal S6 kinase 4, Short name=RSK-4
• Sequence length: 745 AA.
• Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
• Sequence similarities: RSK4 belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. RSK4 contains 1 AGC-kinase C-terminal domain. RSK4 contains 2 protein kinase domains.
• Post-translational modification: Phosphorylated at Ser-232, Ser-372, and Ser-389 in serum-starved cells.
• Subunit structure: RSK4 forms a complex with MAPK3/ERK1 but not with MAPK9 or MAPK14 in serum-starved cells.
• Subcellular location: Cytoplasm › cytosol. Nucleus. Note: Predominantly cytosolic.
• Cofactor: Magnesium
• Enzyme regulation: RSK4 is constitutively activated by phosphorylation at Ser-232, Ser-372, and Ser-389 in serum-starved cells. RSK4 does not require growth factor stimulation for significant kinase activity.

General information above from UniProt

Function for RSK4 (RPS6KA6) Protein

UniProtKB:

RSK4 is constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participates in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.

Genatlas:

• RSK4 IS ribosomal protein S6 kinase, serine/threonine kinase, non receptor type, involved in neuronal development
• RSK4 can participate in non-growth factor signaling as for instance TP53-induced growth arrest (Duemmler 2005)
• RSK4's expression may limit the oncogenic, invasive, and metastatic potential of breast cancer cells (may be, in part, due to its regulation of claudin-2) (Thakur 2008)