RSK3 (RPS6KA2)

RSK3 is serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. RSK3 may function as tumor suppressor in epithelial ovarian cancer cells.

RSK3 (RPS6KA2) Related Areas

Enzyme>>Protein Kinase>>Intracellular Kinase>>Ribosomal Protein S6 Kinase (RSK)>>RSK3/RPS6KA2

Signal Transduction>>Protein Kinase>>Intracellular Kinase>>Ribosomal Protein S6 Kinase (RSK)>>RSK3/RPS6KA2

RSK3 (RPS6KA2) Alternative Names

RSK3, RPS6KA2, RP1-168L15.2, HU-2, MAPKAPK1C, RSK, S6K-alpha, S6K-alpha2, p90-RSK3, pp90RSK3 [Homo sapiens]

Rsk3, Rps6ka2, 90kDa, D17Wsu134e, Rps6ka-rs1, p90rsk, pp90rsk [Mus musculus]

Summaries for RSK3 (RPS6KA2)

Entrez Gene summary for RPS6KA2:

This RPS6KA2 gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. RSK3 contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of RSK3 has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Wikipedia summary for RSK3:

Ribosomal protein S6 kinase alpha-2 is an enzyme that in humans is encoded by the RPS6KA2 gene.

Human RSK3 (RPS6KA2) Protein General Information

 

• Protein names: Ribosomal S6 kinase 3, Short name=RSK-3
• Sequence length: 733 AA.
• Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
• Cofactor: Magnesium.
• Enzyme regulation: Upon extracellular signal or mitogen stimulation, phosphorylated at Thr-570 in the C-terminal kinase domain (CTKD) by MAPK1/ERK2 and MAPK3/ERK1. The activated CTKD then autophosphorylates Ser-377, allowing binding of PDPK1, which in turn phosphorylates Ser-218 in the N-terminal kinase domain (NTDK) leading to the full activation of the protein and subsequent phosphorylation of the substrates by the NTKD.
• Sequence similarities: RSK3 belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. RSK3 contains 1 AGC-kinase C-terminal domain. RSK3 contains 2 protein kinase domains.
• Post-translational modification: RSK3 is activated by phosphorylation at Ser-218 by PDPK1. RSK3 is autophosphorylated on Ser-377, as part of the activation process. RSK3 may be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1
  N-terminal myristoylation results in an activated kinase in the absence of added growth factors
• Subunit structure: RSK3 forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. RSK3 transiently dissociates following mitogenic stimulation
• Subcellular location: Nucleus. Cytoplasm
• Tissue specificity: RSK3 is widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.
• Sequence caution: The sequence AAC82496.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAD92353.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAG53121.1 differs from that shown. Reason: Frameshift at position 527.

General information above from UniProt

Function for RSK3 (RPS6KA2) Protein

UniProtKB:

RSK3 is serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. RSK3 may function as tumor suppressor in epithelial ovarian cancer cells.

Genatlas:

• ribosomal S6 kinase,serine/threonine kinase,non receptor type, RSK3 is not involved in vivo in the phosphorylation of RPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors
• RSK3 maybe plays an essentilal regulatory role in protein synthesis during cell proliferation
• putative tumour suppressor gene at 6q27 in sporadic epithelial ovarian cancer
• RSK3 is critical serine/threonine kinase for the regulation of cell transformation
• RSK3 is key regulator for cell transformation induced by tumor promoters such as EGF and TPA
• RSK3 negatively regulates axon elongation via the MAPK pathway
• RSK3 is important in diverse cellular processes including gene expression, cell proliferation, and survival
• RSK3 is dispensable for BCR-ABL-induced myeloid leukemia, but may be required for pathogenesis and lineage determination in FLT3-ITD-induced hematopoietic transformation