Anti-ROBO4 Antibody

Cat: 11960-RP02
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Anti-ROBO4 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-ROBO4 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human ROBO4
Recombinant Human ROBO4 protein (Catalog#11960-H08H)
Produced in rabbits immunized with purified, recombinant Human ROBO4 (rh ROBO4; Catalog#11960-H08H; Q8WZ75-1; Met 1-Glu 469). ROBO4 specific IgG was purified by Human ROBO4 affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-ROBO4 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-ROBO4 Antibody Alternative Names
Anti-ECSM4 Antibody;Anti-MRB Antibody
ROBO4 Background Information

Roundabout homolog 4, also known as magic roundabout and ROBO4 is a member of the immunoglobulin superfamily and ROBO family. ROBO4 is specifically expressed in endothelial cells. It is expressed at sites of angiogenesis in different tumor types. ROBO4 contains two fibronectin type-III domains and two Ig-like C2-type (immunoglobulin-like) domains. ROBO4 is the fourth identified member of the roundabout receptor family. It is the only Robo family member expressed in primary endothelial cells and that application of Slit inhibits their migration. ROBO4 is predominantly expressed in embryonic or tumor vascular endothelium and is considered important for vascular development and as a candidate tumor endothelial marker. ROBO4 is a bona fide member of the Robo family and may provide a repulsive cue to migrating endothelial cells during vascular development. ROBO4 is a receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. ROBO4 may mediate the inhibition of primary endothelial cell migration by Slit proteins. Activating ROBO4 may have broad therapeutic application in diseases characterized by excessive angiogenesis and/or vascular leak.

Full Name
roundabout, axon guidance receptor, homolog 4 (Drosophila)
  • Huminiecki L., et al., 2002, Genomics 79:547-552.
  • Park,K.W. et al., 2003,Dev Biol. 261 (1):251-67.
  • Yoshikawa,M. et al., 2008, Protein Expr Purif. 61 (1):78-82.
  • Jones,C.A. et al., 2008, Nat Med. 14 (4):448-53.
  • Koch,A.W. et al., 2011, Dev Cell. 20 (1):33-46.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-ROBO4 Antibody Rabbit Polyclonal ELISA 51081-T16
    Anti-ROBO4 Antibody Rabbit Monoclonal ELISA 51081-R036
    Anti-ROBO4 Antibody Rabbit Polyclonal ELISA 51081-RP01
    Anti-ROBO4 Antibody Rabbit Monoclonal ELISA 11960-R003
    Anti-ROBO4 Antibody Rabbit Polyclonal ELISA 11960-RP01
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