RET (Protein|Antibody|cDNA Clone|ELISA Kit)

All RET reagents are produced in house and quality controlled, including 3 RET Antibody, 15 RET Gene, 2 RET Lysate, 2 RET Protein, 1 RET qPCR. All RET reagents are ready to use.

Recombinant RET proteins are expressed by HEK293 Cells, Baculovirus-Insect Cells with fusion tags as C-His, N-GST & His.

RETantibodies are validated with different applications, which are ELISA.

RETcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each RET of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

RET Protein (2)

Species

RET Protein, Human, Recombinant (His Tag)

11997-H08H1

Expression host: HEK293 Cells

Human RET Protein 9928

RET Protein, Human, Recombinant (aa 658-1114, His & GST Tag)

11997-H20B

Expression host: Baculovirus-Insect Cells

Human RET Protein 9929
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RET Antibody (3)

Application
Clonality
Host

Anti-RET Antibody

11997-T16

Application: ELISA

Clonality: PAb

Anti-RET Antibody

11997-R009

Application: ELISA

Clonality: MAb

Anti-RET Antibody

11997-RP01

Application: ELISA

Clonality: PAb

Go

RET cDNA Clone (15)

Human
Mouse
NM_001080780.1

RET qPCR Primer (1)

RET Lysate (2)

RET proto-oncogene, also known as RET, is a cell-surface molecule that transduce signals for cell growth and differentiation. It contains 1 cadherin domain and 1 protein kinase domain. RET proto-oncogene belongs to the protein kinase superfamily, tyr protein kinase family. RET proto-oncogene is involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. It phosphorylates PTK2/FAK1 and regulates both cell death/survival balance and positional information. RET is required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life; promotes the formation of Peyer's patch-like structures; modulates cell adhesion via its cleavage; involved in the development of the neural crest. RET proto-oncogene is active in the absence of ligand, triggering apoptosis. RET acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. It also regulates nociceptor survival and size; triggers the differentiation of rapidly adapting (RA) mechanoreceptors; mediated several diseases such as neuroendocrine cancers. Defects in RET may cause colorectal cancer, hirschsprung disease type 1, medullary thyroid carcinoma, multiple neoplasia type 2B, susceptibility to pheochromocytoma, multiple neoplasia type 2A, thyroid papillary carcinoma and congenital central hypoventilation syndrome.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Protein
Antibody
Gene
qPCR
Lysate
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