Anti-RELT / TNFRSF19L Antibody

Cat: 10530-RP01
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Anti-RELT / TNFRSF19L Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-RELT / TNFRSF19L Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human RELT / TNFRSF19L
Immunogen
Recombinant Human RELT protein (Catalog#10530-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human RELT (rh RELT; Catalog#10530-H08H; NP_116260.2; Met 1-Ala 160). Total IgG was purified by Protein A affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-RELT / TNFRSF19L Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-RELT / TNFRSF19L Antibody Alternative Names
Anti-TNFRSF19L Antibody;Anti-TRLT Antibody
RELT / TNFRSF19L Background Information

Receptor expressed in lymphoid tissues (RELT), also known as tumor necrosis factor receptor superfamily, member 19-like (TNFRSF19L), is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1. RELT/TNFRSF19L is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. RELT/TNFRSF19L is a type I transmembrane glycoprotein with a cysteine-rich extracellular domain, possessing significant homology to other members of the TNFR superfamily, especially TNFRSF19, DR3, OX40, and LTbeta receptor. RELT/TNFRSF19L is able to activate the NF-kappaB pathway and selectively binds tumor necrosis factor receptor-associated factor 1. RELT/TNFRSF19L is able to activate the NF-κB pathway and selectively binds tumor necrosis factor receptor-associated factor 1. Although the soluble form of RELT fusion protein does not inhibit the one-way mixed lymphocyte reaction, immobilized RELT/TNFRSF19L is capable of costimulating T-cell proliferation in the presence of CD3 signaling.

Full Name
RELT tumor necrosis factor receptor
References
  • Sica GL, et al. (2001) RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-kappaB. Blood. 97(9): 2702-7.
  • Polek TC, et al. (2006) The TNF receptor, RELT, binds SPAK and uses it to mediate p38 and JNK activation. Biochem Biophys Res Commun. 343(1): 125-34.
  • Cusick JK, et al. (2006) Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1. Biochem Biophys Res Commun. 340(2): 535-43.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-RELT / TNFRSF19L Antibody Rabbit Polyclonal ELISA 10530-RP02
    Anti-RELT / TNFRSF19L Antibody Rabbit Monoclonal ELISA(Cap) 10530-R111
    Anti-RELT / TNFRSF19L Antibody Rabbit Monoclonal ELISA,ELISA(Det) 10530-R135
    Anti-RELT / TNFRSF19L Antibody Mouse Monoclonal ICC/IF,IF 10530-MM01
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