Anti-RELT / TNFRSF19L Antibody

Cat: 10530-MM01
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Anti-RELT / TNFRSF19L Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-RELT / TNFRSF19L Antibody
Validated applications
ICC/IF,IF
Species reactivity
Reacts with: Human
Specificity
Human RELT / TNFRSF19L
Immunogen
Recombinant Human RELT / TNFRSF19L protein (Catalog#10530-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human RELT / TNFRSF19L (rh RELT / TNFRSF19L; Catalog#10530-H08H; NP_116260.2; Met1-Ala160). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG2b Clone #01
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-RELT / TNFRSF19L Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ICC-IF 1:20-1:100  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-RELT / TNFRSF19L Antibody (Mouse Monoclonal antibody) Images
Human RELT/TNFRSF19L Immunohistochemistry(IHC) 5474
Confocal immunofluorescence analysis of Human RELT in SKBR3 cells. Cells were fixed with 4% PFA, permeabilzed with 1% Triton X-100 in PBS, blocked with 10% serum, and incubated with Mouse anti-Human RELT monoclonal antibody (1:60) at 37℃ 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-mouse IgG secondary antibody (green). Positive staining was localized to cytoplasm and plasma membrane.
Anti-RELT / TNFRSF19L Antibody Alternative Names
Anti-TNFRSF19L Antibody;Anti-TRLT Antibody
RELT / TNFRSF19L Background Information

Receptor expressed in lymphoid tissues (RELT), also known as tumor necrosis factor receptor superfamily, member 19-like (TNFRSF19L), is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1. RELT/TNFRSF19L is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. RELT/TNFRSF19L is a type I transmembrane glycoprotein with a cysteine-rich extracellular domain, possessing significant homology to other members of the TNFR superfamily, especially TNFRSF19, DR3, OX40, and LTbeta receptor. RELT/TNFRSF19L is able to activate the NF-kappaB pathway and selectively binds tumor necrosis factor receptor-associated factor 1. RELT/TNFRSF19L is able to activate the NF-κB pathway and selectively binds tumor necrosis factor receptor-associated factor 1. Although the soluble form of RELT fusion protein does not inhibit the one-way mixed lymphocyte reaction, immobilized RELT/TNFRSF19L is capable of costimulating T-cell proliferation in the presence of CD3 signaling.

Full Name
RELT tumor necrosis factor receptor
References
  • Sica GL, et al. (2001) RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-kappaB. Blood. 97(9): 2702-7.
  • Polek TC, et al. (2006) The TNF receptor, RELT, binds SPAK and uses it to mediate p38 and JNK activation. Biochem Biophys Res Commun. 343(1): 125-34.
  • Cusick JK, et al. (2006) Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1. Biochem Biophys Res Commun. 340(2): 535-43.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-RELT / TNFRSF19L Antibody Rabbit Polyclonal ELISA 10530-RP02
    Anti-RELT / TNFRSF19L Antibody Rabbit Polyclonal ELISA 10530-RP01
    Anti-RELT / TNFRSF19L Antibody Rabbit Monoclonal ELISA(Cap) 10530-R111
    Anti-RELT / TNFRSF19L Antibody Rabbit Monoclonal ELISA,ELISA(Det) 10530-R135
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