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RELA / Transcription factor p65 Protein

V-rel reticuloendotheliosis viral oncogene homolog A (avian)

RELA / Transcription factor p65 Products

RELA / Transcription factor p65 Protein, Recombinant

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
RELA Human RELA/Transcription factor p65 (aa 1-306) Protein, Recombinant, with GST Tag 12054-H09E

RELA / Transcription factor p65 Antibody

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human RELA ELISA RELA / Transcription factor p65 Antibody 12054-MM03

RELA / Transcription factor p65 cDNA Clone

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
RELA Human Human RELA cDNA Clone / ORF Clone HG12054-G
RELA Human Human RELA ORF Expression Clone, Myc-tagged HG12054-G-M
RELA Human Human RELA ORF Expression Clone, HA-tagged HG12054-G-Y

RELA / Transcription factor p65 Alternative Names

RELA, MGC131774, NFKB3, p65 [Homo sapiens]

Rela, p65 [Mus musculus]

RELA / Transcription factor p65 Background

RELA (v-rel reticuloendotheliosis viral oncogene homolog A), also known as Nuclear factor NF-kappa-B p65 subunit, or Transcription factor p65, is a transcription factor expressed in growth plate chondrocytes where it facilitates chondrogenesis. The v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) gene encodes the major component of the NF-?B complex. NF-kappaB is a generic name for an evolutionarily conserved transcription-factor system that contributes to the mounting of an effective immune response but is also involved in the regulation of cell proliferation, development, and apoptosis. The implication of NF-kappaB in central biological processes and its extraordinary connectivity to other signaling pathways raise a need for highly controlled regulation of NF-kappaB activity at several levels. The mammalian Rel/NF-kappaB family of transcription factors, including RelA, c-Rel, RelB, NF-kappaB1 (p50 and its precursor p105), and NF-kappaB2 (p52 and its precursor p100), plays a central role in the immune system by regulating several processes ranging from the development and survival of lymphocytes and lymphoid organs to the control of immune responses and malignant transformation.

RELA / Transcription factor p65 Related Studies

  1. Hashimoto R, et al. (2011) Variants of the RELA gene are associated with schizophrenia and their startle responses. Neuropsychopharmacology. 36(9): 1921-31.
  2. Wu S, et al. (2011) Nuclear factor-kappaB (NF-kappaB) p65 interacts with Stat5b in growth plate chondrocytes and mediates the effects of growth hormone on chondrogenesis and on the expression of insulin-like growth factor-1 and bone morphogenetic protein-2. J Biol Chem. 286(28): 24726-34.
  3. Vallabhapurapu S, et al. (2009) Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol. 27: 693-733.
  4. Schmitz ML, et al. (2004) NF-kappaB: a multifaceted transcription factor regulated at several levels. Chembiochem. 5(10): 1348-58.

 

 

RELA / Transcription factor p65 / NFkB p65 related areas, pathways, and other information

 

 

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