- EGFR Signaling Pathway
- TGF-beta Signaling
- Canonical Wnt Signaling
- non-Canonical Wnt Signaling
- Notch Signaling
- p53 Pathway
- NF-kB Pathway
- Cytokine Signaling
|Catalog||Size (Price)||Quantity||In Stock||Operation|
Lectin, galactoside-binding, soluble, 1 Protein Datasheet
REG4 Protein Price Inquiry ( Available Sizes )
REG4 Protein Product Information
A DNA sequence encoding the rat REG4 (Q68AX7) (Met1-Pro157) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
|Expression Host:||Human Cells|
REG4 Protein QC Testing
|Purity:||> 80% as determined by SDS-PAGE||SDS-PAGE:
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Asp 23|
The recombinant rat REG4/Fc is a disulfide-linked homodimer. The reduced monomer comprises 376 amino acids and has a predicted molecular mass of 42.9 kDa. The apparent molecular mass of the protein is approximately 49 kDa in SDS-PAGE under reducing conditions.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
REG4 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
REG4 Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|REG4||Human||REG4 Protein, Recombinant||11186-H08H|
|REG4||Mouse||REG4 Protein, Recombinant||50202-M08H|
|REG4||Rat||REG4 Protein, Recombinant||80249-R02H|
|REG4||Rat||REG4 Protein, Recombinant||80249-R08H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|WB, ELISA||REG4 Antibody, Rabbit PAb||11186-RP01|
|WB, ELISA||REG4 Antibody, Rabbit PAb (Antigen Affinity Purified)||11186-RP02|
|WB, ELISA||REG4 Antibody||11186-R018|
REG4 Protein Description
Regenerating islet-derived protein 4, also known as REG-like protein, REG4, GISP and RELP, is a secreted protein which contains one C-type lectin domain. REG4 is involved in inflammatory and metaplastic responses of the gastrointestinal epithelium. REG4 is highly expressed in the gastrointestinal tract including the duodenum, jejunum, ileum, ileocecum, appendix, descending colon, pancreas and small intestine. It is weakly expressed in normal colon and stomach and strongly expressed in most colorectal tumors than in normal colon. It is also preferentialy expressed in mucinous tumors and in some cases neuro-endocrine tumors. REG4 protein overexpression is associated with an unfavorable response to preoperative chemoradiotherapy and may be used as a predictive biomarker clinically. REG4 is also a promising tumor marker to screen early-stage Pancreatic ductal adenocarcinoma (PDAC), and neutralization of REG4 by the antibody may offer novel potential tools for the treatment of PDAC.
- Hartupee JC. et al., 2001, Biochim Biophys Acta. 1518: 287-93.
- Violette S. et al., 2003, Int J Cancer 103: 185-93.
- Kaemaeraeinen M. et al., 2003, Am J Pathol. 163: 11-20.
- Takehara A. et al., 2006, Cancer Sci. 97 (11): 1191-7.
- Eguchi H. et al., 2009, Pancreas. 38 (7): 791-8.