REG4 Protein & Antibody

Regenerating islet-derived family, member 4

REG4 Products

REG4 Protein, Recombinant

Molecule	Species	Description	Cat. No
REG4	Human	REG4 Protein, Recombinant	11186-H08H
REG4	Mouse	REG4 Protein, Recombinant	50202-M08H

  11186-H08H:  The ED₅₀ for this effect is typically 2-6 µg/mL. Measured by the ability of the immobilized protein to support the adhesion and proliferation of HCT-116 human colorectal carcinoma cells (ATCC: CCL-247) under low serum conditions..

  50202-M08H: When 5 x 10⁴ cells/well are added to mouse REG4 coated plates (0.16 µg/mL and 100 µL/well), > 70% cell will adhere after 60 minutes at 37℃. Measured by the ability of the immobilized protein to support the adhesion and proliferation of HCT-116 human colorectal carcinoma cells (ATCC: CCL-247) under low serum conditions..

REG4 Antibody

Molecule	Application	Description	Cat. No
Human REG4	WB, ELISA	REG4 Antibody, Rabbit PAb	11186-RP01
Human REG4	WB, ELISA	REG4 Antibody, Rabbit PAb (Antigen Affinity Purified)	11186-RP02
Human REG4	WB, ELISA	REG4 Antibody	11186-R018

REG4 cDNA Clone

Molecule	Species	Description	Cat. No
REG4	Human	Homo sapiens REG4 cDNA Clone(NM_032044.2)	HG11186-M
REG4	Mouse	Mus musculus REG4 cDNA Clone	MG50202-M
REG4	Rat	REG4 cDNA Clone / ORF Clone	RG80249-G

REG4 Related Areas

Immunology>>Adhesion Molecule>>Lectin>>REG4

Cancer>>Cancer Biomarkers>>REG4

REG4 Alternative Names

REG4, REG-4, GISP, REG-IV, RELP[Homo sapiens]

REG4, REG-4, 2010002L15Rik, GISP, RELP [Mus musculus]

REG4 Related Products

Protein Products

Molecule	Species	Description
REG1A	Human	REG1A Protein, Recombinant
REG1B	Human	REG1B Protein, Recombinant
REG3A	Human	REG3A Protein, Recombinant
REG3A	Mouse	REG3A Protein, Recombinant
REG3D	Mouse	REG3D Protein, Recombinant
REG3G	Human	REG3G Protein, Recombinant

Antibody Products

Molecule	Application	Description
Human REG1A	WB, ELISA	Rabbit Polyclonal Antibody
Human REG1A	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human REG1B	WB, ELISA	REG1B Antibody, Rabbit PAb
Human REG1B	WB, ELISA	REG1B Antibody, Rabbit PAb (Antigen Affinity Purified)
Human REG3A	WB, ELISA	REG3A Antibody, Rabbit PAb
Human REG3A	WB, ELISA	REG3A Antibody, Rabbit PAb (Antigen Affinity Purified)
Human REG3G	WB, ELISA	REG3G Antibody, Rabbit MAb
Human REG3G	WB, ELISA	REG3G Antibody, Rabbit PAb
Human REG3G	WB, ELISA	REG3G Antibody, Rabbit PAb (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description
REG1A	Human	Homo sapiens REG1A cDNA Clone(NM_002909.4)
REG1B	Human	Homo sapiens REG1B cDNA Clone
REG3A	Human	Homo sapiens REG3A cDNA Clone(NM_002580.1)
REG3A	Mouse	Mus musculus REG3A cDNA Clone
REG3D	Mouse	Mus musculus REG3D cDNA Clone
REG3G	Human	Homo sapiens REG3G cDNA Clone

REG4 Background

Regenerating islet-derived protein 4, also known as REG-like protein, REG4, GISP and RELP, a member of the regenerating gene family belonging to the calcium (C-type) dependent lectin superfamily, has been found to be involved in malignancy in several different organs including the stomach, colorectum, pancreas and prostate. It is highly expressed in the gastrointestinal tract and markedly up-regulated in colon adenocarcinoma, pancreatic cancer, gastric adenocarcinoma, and inflammatory bowel disease. Expression of the Reg4 in different cell types has been associated with regeneration, cell growth and cell survival, cell adhesion and resistance to apoptosis. REG4 protein overexpression is associated with an unfavorable response to preoperative chemoradiotherapy and may be used as a predictive biomarker clinically. REG4 may play an important role in the development and progression of colorectal cancer, as well as in intestinal morphogenesis and epithelium restitution.

REG4 Related Studies

1. Li FY, et al. (2010) RegIV expression showing specificity to gastrointestinal tract and its potential role in diagnosing digestive tract neuroendocrine tumor. J Zhejiang Univ Sci B. 11(4):258-66.
2. Rafa L, et al. (2010) REG4 acts as a mitogenic, motility and pro-invasive factor for colon cancer cells. Int J Oncol. 36(3): 689-98.
3. Hu G, et al. (2010) Purification of a bioactive recombinant human Reg IV expressed in Escherichia coli. Protein Expr Purif. 69(2): 186-90.