Anti-REG4 Antibody

Cat: 11186-RP02
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Anti-REG4 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-REG4 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human REG4
Immunogen
Recombinant Human REG4 protein (Catalog#11186-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human REG4 (rh REG4; Catalog#11186-H08H; NP_001152824.1; Met 1-Pro 158). REG4 specific IgG was purified by human REG4 affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-REG4 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-REG4 Antibody Alternative Names
Anti-GISP Antibody;Anti-REG-IV Antibody;Anti-RELP Antibody
REG4 Background Information

Regenerating islet-derived protein 4, also known as REG-like protein, REG4, GISP and RELP, a member of the regenerating gene family belonging to the calcium (C-type) dependent lectin superfamily, has been found to be involved in malignancy in several different organs including the stomach, colorectum, pancreas and prostate. It is highly expressed in the gastrointestinal tract and markedly up-regulated in colon adenocarcinoma, pancreatic cancer, gastric adenocarcinoma, and inflammatory bowel disease. Expression of the Reg4 in different cell types has been associated with regeneration, cell growth and cell survival, cell adhesion and resistance to apoptosis. REG4 protein overexpression is associated with an unfavorable response to preoperative chemoradiotherapy and may be used as a predictive biomarker clinically. REG4 may play an important role in the development and progression of colorectal cancer, as well as in intestinal morphogenesis and epithelium restitution.

Full Name
regenerating islet-derived family, member 4
References
  • Li FY, et al. (2010) RegIV expression showing specificity to gastrointestinal tract and its potential role in diagnosing digestive tract neuroendocrine tumor. J Zhejiang Univ Sci B. 11(4):258-66.
  • Rafa L, et al. (2010) REG4 acts as a mitogenic, motility and pro-invasive factor for colon cancer cells. Int J Oncol. 36(3): 689-98.
  • Hu G, et al. (2010) Purification of a bioactive recombinant human Reg IV expressed in Escherichia coli. Protein Expr Purif. 69(2): 186-90.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-REG4 Antibody Rabbit Polyclonal ELISA,IHC-P 80249-T08
    Anti-REG4 Antibody Mouse Monoclonal ELISA(Cap) 11186-MM05
    Anti-REG4 Antibody Rabbit Polyclonal ELISA 11186-RP01
    Anti-REG4 Antibody Rabbit Monoclonal IHC-P 11186-R244
    Anti-REG4 Antibody Mouse Monoclonal ELISA(Det) 11186-MM01
    Anti-REG4 Antibody Rabbit Monoclonal ELISA 11186-R018
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