REG3G Protein & Antibody

Regenerating islet-derived 3 gamma

REG3G Products

REG3G Protein, Recombinant

Molecule	Species	Description	Cat. No
REG3G	Human	REG3G Protein, Recombinant	11641-H08H

REG3G Antibody

Molecule	Application	Description	Cat. No
Human REG3G	WB, ELISA	REG3G Antibody, Rabbit MAb	11641-R002
Human REG3G	WB, ELISA	REG3G Antibody, Rabbit PAb	11641-RP01
Human REG3G	WB, ELISA	REG3G Antibody, Rabbit PAb (Antigen Affinity Purified)	11641-RP02

REG3G cDNA Clone

Molecule	Species	Description	Cat. No
REG3G	Human	Homo sapiens REG3G cDNA Clone	HG11641-M
REG3G	Mouse	Mouse REG3G cDNA Clone / ORF Clone	MG50949-G

REG3G Related Areas

Immunology>>Adhesion Molecule>>Lectin>>REG3G

REG3G Alternative Names

REG3G, UNQ429/PRO162, MGC118998, MGC118999, MGC119001, PAP IB, PAP1B, PAPIB, REG-III, UNQ429 [Homo sapiens]

Reg3g, AI449515 [Mus musculus]

REG3G Related Products

Protein Products

Molecule	Species	Description
REG1A	Human	REG1A Protein, Recombinant
REG1B	Human	REG1B Protein, Recombinant
REG3A	Human	REG3A Protein, Recombinant
REG3A	Mouse	REG3A Protein, Recombinant
REG3D	Mouse	REG3D Protein, Recombinant
REG4	Human	REG4 Protein, Recombinant
REG4	Mouse	REG4 Protein, Recombinant

Antibody Products

Molecule	Application	Description
Human REG1A	WB, ELISA	Rabbit Polyclonal Antibody
Human REG1A	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human REG1B	WB, ELISA	REG1B Antibody, Rabbit PAb
Human REG1B	WB, ELISA	REG1B Antibody, Rabbit PAb (Antigen Affinity Purified)
Human REG3A	WB, ELISA	REG3A Antibody, Rabbit PAb
Human REG3A	WB, ELISA	REG3A Antibody, Rabbit PAb (Antigen Affinity Purified)
Human REG4	WB, ELISA	REG4 Antibody, Rabbit PAb
Human REG4	WB, ELISA	REG4 Antibody, Rabbit PAb (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description
REG1A	Human	Homo sapiens REG1A cDNA Clone(NM_002909.4)
REG1B	Human	Homo sapiens REG1B cDNA Clone
REG3A	Human	Homo sapiens REG3A cDNA Clone(NM_002580.1)
REG3A	Mouse	Mus musculus REG3A cDNA Clone
REG3D	Mouse	Mus musculus REG3D cDNA Clone
REG4	Human	Homo sapiens REG4 cDNA Clone(NM_032044.2)
REG4	Mouse	Mus musculus REG4 cDNA Clone

REG3G Background

Regenerating gene (Reg), first isolated from a regenerating islet cDNA library, encodes a secretory protein with a growth stimulating effect on pancreatic beta cells. Reg and Reg-related genes which were expressed in various organs have been revealed to constitute a multigene family, the Reg family, which consists of four subtypes (types I, II, III, IV) based on the primary structures of the encoded proteins of the genes, which are associated with tissue repair and have been directly implicated in pancreatic beta-cell regeneration. Reg proteins are expressed in various organs and are involved in cancers and neurodegenerative diseases. They display a typical C-type lectin-like domain but possess additional highly conserved amino acids. Regenerating islet-derived 3 gamma (REG3G), also known as pancreatitis-associated protein 1B (PAP1B), is a member of the secreted Reg superfamily and contains one typical C-type lectin domain. REG3G is expressed weakly in pancreas, strongly in intestinal tract, but not in hyperplastic islets REG3G might be a stress protein involved in the control of bacterial proliferation. It was indicated that REG3G specifically targets Gram-positive bacteria because it binds to their surface peptidoglycan layer, and serves as one of several antimicrobial peptides produced by paneth cells via stimulation of toll-like receptors (TLRs) by pathogen-associated molecular patterns (PAMPs).

REG3G Related Studies

1. Narushima Y, et al. (1997) Structure, chromosomal localization and expression of mouse genes encoding type III Reg, RegIII alpha, RegIII beta, RegIII gamma. Gene. 185(2): 159-68.
2. Nata K, et al. (2004) Molecular cloning, expression and chromosomal localization of a novel human REG family gene, REG III. Gene. 340(1): 161-70.
3. Laurine E, et al. (2005) PAP IB, a new member of the Reg gene family: cloning, expression, structural properties, and evolution by gene duplication. Biochim Biophys Acta. 1727(3): 177-87.
4. Castellarin ML, et al. (2007) The identification and sequence analysis of a new Reg3gamma and Reg2 in the Syrian golden hamster. Biochim Biophys Acta. 1769(9-10): 579-85.