REG3A

Regenerating islet-derived protein 3-alpha, also known as Regenerating islet-derived protein III-alpha, REG-3-alpha, REG3A, and HIP, is secreted protein which contains one C-type lectin domain. REG3A is constitutively expressed in intestine, and is a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It is overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis. REG3A and REG1A proteins are both involved in liver and pancreatic regeneration and proliferation. REG3A is also a stress protein involved in the control of bacterial proliferation. REG3A is down-regulated in most primary human gastric cancer cells, and might be useful in the diagnosis of gastric cancer. Additionally, REG3A is a target of beta-catenin signaling in Huh7 hepatoma cells. The REG1A and REG3A are downstream targets of the Wnt pathway during liver tumorigenesis.

REG3A Related Areas

Immunology>>Adhesion Molecule>>Lectin>>REG3A

REG3A Alternative Names

REG3A, HIP, PAP, PAP-H, PAP1, PBCGF, REG-III, REG3 [Homo sapiens] Reg3a, AV063448 [Mus musculus]

Summaries for REG3A

Entrez Gene summary for REG3A :

This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. Alternate splicing results in multiple transcript variants that encode the same protein.

OMIM - description for REG3A :

Using a rat PAP cDNA to screen a human pancreatic cDNA library, Orelle et al. (1992) isolated the human equivalent. The predicted protein had the same size as the rat protein and showed 71% amino acid identity, the 6 half-cysteines being in identical positions. As in the rat, the protein was expressed at very low levels in control tissues and overexpressed during the acute phase of pancreatitis in humans. The protein could be immunolocalized to the apical regions of acinar cells. The protein was also quantifiable in serum with an elevation of levels in pancreatitis, suggesting its possible use as a biologic marker of the disease.

Wikipedia summary for REG3A :

Regenerating islet-derived protein 3 alpha is a protein that in humans is encoded by the REG3A gene.[1][2] This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. Multiple alternatively spliced transcript variants encoding the same protein have been described for this gene but the full length nature of some transcripts is not yet known

Human REG3A Protein General Information

 

• Protein names: Submitted name: Proliferation-inducing protein 34
• Sequence length: 175 AA.
• Domain: Signal
• Sequence similarities: Contains 1 C-type lectin domain.
• Subunit structure: Appears in pancreatic juice after induction of pancreatic inflammation.
• Subcellular location: Secreted. Note: Found in the apical region of pancreatic acinar cells.
• Tissue specificity: Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis.

General information above from UniProt

Function for REG3A Protein

UniProtKB:

Might be a stress protein involved in the control of bacterial proliferation.

Genatlas:

• REG3A inducing new pancreatic islets development
• REG3A may be a stress protein involved in the control of bacterial proliferation

Phenotype Information for REG3A

Phenotype Information for REG3A from OMIM (Online Mendelian Inheritance in Man)

Drugs for REG3A

Drugs for REG3A from TTD (Therapeutic Targets Database)