REG1B Protein & Antibody

Regenerating islet-derived 1 beta

REG1B Products

REG1B Protein, Recombinant

Molecule	Species	Description	Cat. No
REG1B	Human	REG1B Protein, Recombinant	11638-H08H

REG1B Antibody

Molecule	Application	Description	Cat. No
Human REG1B	WB, ELISA	REG1B Antibody, Rabbit PAb	11638-RP01
Human REG1B	WB, ELISA	REG1B Antibody, Rabbit PAb (Antigen Affinity Purified)	11638-RP02

REG1B cDNA Clone

Molecule	Species	Description	Cat. No
REG1B	Human	Homo sapiens REG1B cDNA Clone	HG11638-M

REG1B Related Areas

Immunology>>Adhesion Molecule>>Lectin>>REG1B

REG1B Alternative Names

REG1B, PSPS2, REGH, REGI-BETA, REGL, PSP-2, REG-1-beta [Homo sapiens]

REG1B Related Products

Protein Products

Molecule	Species	Description
REG1A	Human	REG1A Protein, Recombinant
REG3A	Human	REG3A Protein, Recombinant
REG3A	Mouse	REG3A Protein, Recombinant
REG3D	Mouse	REG3D Protein, Recombinant
REG3G	Human	REG3G Protein, Recombinant
REG4	Human	REG4 Protein, Recombinant
REG4	Mouse	REG4 Protein, Recombinant

Antibody Products

Molecule	Application	Description
Human REG1A	WB, ELISA	Rabbit Polyclonal Antibody
Human REG1A	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human REG3A	WB, ELISA	REG3A Antibody, Rabbit PAb
Human REG3A	WB, ELISA	REG3A Antibody, Rabbit PAb (Antigen Affinity Purified)
Human REG3G	WB, ELISA	REG3G Antibody, Rabbit MAb
Human REG3G	WB, ELISA	REG3G Antibody, Rabbit PAb
Human REG3G	WB, ELISA	REG3G Antibody, Rabbit PAb (Antigen Affinity Purified)
Human REG4	WB, ELISA	REG4 Antibody, Rabbit PAb
Human REG4	WB, ELISA	REG4 Antibody, Rabbit PAb (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description
REG1A	Human	Homo sapiens REG1A cDNA Clone(NM_002909.4)
REG3A	Human	Homo sapiens REG3A cDNA Clone(NM_002580.1)
REG3A	Mouse	Mus musculus REG3A cDNA Clone
REG3D	Mouse	Mus musculus REG3D cDNA Clone
REG3G	Human	Homo sapiens REG3G cDNA Clone
REG4	Human	Homo sapiens REG4 cDNA Clone(NM_032044.2)
REG4	Mouse	Mus musculus REG4 cDNA Clone

REG1B Background

Regenerating gene (Reg), first isolated from a regenerating islet cDNA library, encodes a secretory protein with a growth stimulating effect on pancreatic beta cells, and could be associated with fibrocalculous pancreatopathy. Reg and Reg-related genes which were expressed in various organs have been revealed to constitute a multigene family, the Reg family consisting of four subtypes (types I, II, III, IV) and are involved in cancers and neurodegenerative diseases. Regenerating islet-derived 1 beta (REG1B), also known as Lithostathine-1-beta and Pancreatic stone protein 2 (PSPS2), is a types I Reg protein and contains one typical C-type lectin domain. REG1B is a 166-amino acid protein which has 22 amino acid substitutions in comparison with the previously isolated human REG1A, and it is was expressed only in pancreas. REG1B Is normally found in the exocrine pancreas, whereas in other tissues it appears either only under pathological conditions, such as Alzheimer's disease (brain), cancer (colon), or during regeneration such as neuronal sprouting in brain and pancreas regeneration. REG1B might act as an inhibitor of spontaneous calcium carbonate precipitation. The REG1A and REG1B gene and proteins could play different roles in the pancreas.

REG1B Related Studies

1. Moriizumi S, et al. (1994) Isolation, structural determination and expression of a novel reg gene, human regI beta. Biochim Biophys Acta. 1217(2): 199-202.
2. Sanchez D, et al. (2001) Preferential expression of reg I beta gene in human adult pancreas. Biochem Biophys Res Commun. 284(3): 729-37.
3. Boonyasrisawat W, et al. (2002) Analysis of the reg1alpha and reg1beta gene transcripts in patients with fibrocalculous pancreatopathy. Southeast Asian J Trop Med Public Health. 33(2): 365-72.